What are the responsibilities and job description for the Scientist/Research Scientist - Immunology position at Valora Therapeutics, Inc.?

About Valora Therapeutics Inc. :

Valora Therapeutics Inc. (Valora) is a pre-clinical stage biopharmaceutical company based in San Diego, California, USA, pioneering a new biologic platform invented by Nobel Laureate Dr. Carolyn Bertozzi (Stanford). Our proprietary platform technology enables the engineering of chimeric antibodies to unlock new mechanisms of immune signaling and activity, paving the way for transformative therapies in oncology, immune diseases, and beyond.

About the Opportunity :

Valora is excited to expand our Immunology team and is looking for a highly motivated scientist to support our R&D Operations in developing next-generation antibody therapeutics using our proprietary chimeric antibody platform. This role will focus on hands-on laboratory work and will include activities such as the following :

In this position, you will :

Design and execute experiments to evaluate novel engineered antibodies, demonstrating critical thinking and problem-solving skills.
Develop and optimize in vitro and ex vivo assays to elucidate cellular and molecular immunological mechanisms.
Analyze complex datasets, interpret results, and present findings to cross-functional teams.
Contribute to the development of new hypotheses and experimental approaches in team discussions.
Stay current with the latest advancements in immunology and antibody engineering, applying this knowledge to ongoing projects.

About You :

Education and Experience :

For Scientist I : PhD in immunology, or a related field. Experience in a biopharmaceutical industry setting is valued but not required.

For Research Scientist : a master’s degree with 6 years of experience or bachelor’s degree with 8 . Experience in the biopharmaceutical industry setting is required.

Technical Skills and Knowledge : skills desired

Strong foundation in cellular and molecular immunology, with expertise in NK cell, macrophage, or T cell biology

In-depth understanding of immuno-oncology concepts and mechanisms

Knowledge of glycobiology and glyco-immunology is desirable

Molecular immunology assays to interrogate signaling pathways and evaluate mechanisms of action

Proficiency in the following laboratory techniques :

a) Functional assays such as (1) Cytotoxicity assays (e.g., 51Cr release, LDH release, real-time cell analysis), (2) Proliferation assays (e.g., CFSE dilution, 3H-thymidine incorporation), (3) Cytokine production and secretion assays (e.g., ELISPOT, intracellular cytokine staining), (4) Antibody-dependent cellular cytotoxicity / phagocytosis (ADCC / ADCP) and complement-dependent cytotoxicity (CDC) assays

b) Multi-color flow cytometry for immunophenotyping and functional readouts

c) MSD, Luminex, or other multiplex assays for analyte measurement

d) Molecular immunology assays to interrogate signaling pathways and evaluate mechanisms of action

Experience with primary cell isolation and culture techniques

Familiarity with antibody engineering concepts and methods, including Fc engineering for enhanced effector functions, Bispecific and multi-specific antibody formats, etc.

General Scientific Skills :

Strong analytical and data interpretation skills, with the ability to integrate complex datasets from multiple assay types

Proficiency in statistical analysis and data visualization tools (e.g., GraphPad Prism, etc)

Excellent documentation practices and attention to detail, including experience with electronic lab notebooks (ELNs)

Ability to design and execute well-controlled experiments, including power analysis for appropriate sample size determination

Experience with systematic literature review and critical evaluation of scientific papers, including meta-analysis techniques

Familiarity with project management tools and techniques to coordinate complex experimental workflows

Experience with literature review and critical evaluation of scientific papers

Personal Qualities :

Demonstrated ability to think critically and approach scientific problems creatively

Strong communication skills, both written and verbal, for presenting complex scientific concepts

Collaborative mindset with the ability to work effectively in cross-functional teams

Adaptability and willingness to learn new techniques and concepts quickly

Self-motivated with the ability to work independently and as part of a team

Passion for scientific innovation and drug discovery

We Offer :

The opportunity to be at the forefront of groundbreaking antibody therapeutic development.

A collaborative and supportive team environment with a highly dynamic and entrepreneurial environment.

Compensation :

In addition to a competitive compensation package with stock options, the company also offers a comprehensive benefits package for our employees and their families, which includes medical, dental, vision, and supplemental disability insurance.

Job Type :

Full-time, 5 days a week presence at the laboratories (this is not a remote work).

Benefits :

401(k)

Dental insurance

Employee assistance program

Flexible schedule

Flexible spending account

Health insurance

Life insurance

Paid time off

Parental leave

Retirement plan

Vision insurance

Voluntary insurance coverage

Join Valora Therapeutics and unleash the potential of protein engineering to revolutionize medicine!

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Scientist/Research Scientist - Immunology

What are the responsibilities and job description for the Scientist/Research Scientist - Immunology position at Valora Therapeutics, Inc.?

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