What are the responsibilities and job description for the Bioconjugation Scientist position at Veranova L P?
Company Description
Veranova is a global leader in the development and manufacturing of complex active pharmaceutical ingredients (APIs) for pharma and biotech customers. With deep technical expertise and impressive flexibility, we develop solutions and processes that support and accelerate innovation.
Position Overview
We are seeking a highly motivated and skilled Bioconjugation Scientist to join our team in New England. The successful candidate will play a hands on role in the development optimization and scale up of bioconjugation processes for the production of antibody drug conjugates ADC's biologics and other complex bioconjugates this position offers an exciting opportunity to contribute to the advancement of cutting edge biotherapeutics in a fast-paced collaborative environment.
Key Responsibilities:
• Develop and optimize bioconjugation strategies for the attachment of cytotoxic payloads, biomolecules, or other small molecules to antibodies, proteins, peptides, or other therapeutic entities.
• Work closely with other scientists and engineers to scale-up and transfer bioconjugation processes from bench to cGMP manufacturing.
• Troubleshoot and resolve issues related to bioconjugation, including yield optimization, purity, and stability of final products.
• Perform comprehensive analysis of bioconjugates using techniques such as HPLC, mass spectrometry, SDS-PAGE, SEC, and UV-Vis spectrophotometry.
• Quantify drug-to-antibody ratio (DAR), assess conjugate stability, and characterize impurities.
• Develop and validate analytical methods for assessing the quality and consistency of bioconjugates.
• Collaborate with manufacturing teams to ensure smooth technology transfer from laboratory to pilot scale and full-scale production.
• Provide support for cGMP manufacturing campaigns, ensuring compliance with regulatory requirements and documentation standards.
• Assist in troubleshooting manufacturing issues and process optimization to improve product yields and quality.
• Work closely with process engineers, quality control, analytical development, and regulatory affairs teams to ensure successful project delivery.
• Communicate technical findings and results to both internal and external stakeholders, including clients and regulatory bodies.
• Prepare and maintain detailed documentation of experimental procedures, results, and data analysis in compliance with GMP, GLP, and internal quality standards.
• Support regulatory submissions by providing technical input, data packages, and scientific justifications.
Qualifications:
- Ph.D., M.S., or B.S. in Biochemistry, Biotechnology, Chemistry, or related field with relevant experience in bioconjugation, protein chemistry, or chemical biology.
o For Ph.D. candidates: 2 years of post-doctoral or industry experience in bioconjugation, ADC development, or protein chemistry.
o For M.S. candidates: 4 years of experience in bioconjugation and biopharmaceutical development.
o For B.S. candidates: 6 years of hands-on experience in a CDMO or biopharmaceutical setting.
- Strong knowledge of bioconjugation techniques (e.g., site-specific conjugation, linker chemistry, ADC development).
- Experience with analytical techniques such as mass spectrometry, HPLC, and protein characterization.
- Familiarity with GMP, GLP, and regulatory guidelines for biologic product development.
- Ability to design and execute experiments, analyze complex data, and troubleshoot bioconjugation challenges.
- Strong communication and teamwork skills in a cross-functional environment.
Desired Qualifications:
• Experience with clinical-stage biologics or commercial-scale ADC manufacturing.
• Knowledge of process modeling and automation tools.
• Familiarity with protein expression systems, purification, and conjugation of various biologic modalities.
Additional Information
All your information will be kept confidential according to EEO guidelines.
Veranova is an Equal Opportunity Employer. It is the policy of Veranova to provide equal employment access and opportunity to all persons regardless of age, race, color, national origin, religion, sex, sexual orientation, gender identity and/or expression, physical or mental disability, genetic information, citizenship, marital status, veteran status, or any other characteristic protected by federal, state, or local law.
All applications are carefully considered, and your details will be stored on our secure Application Management System. This is used throughout Veranova for the selection of suitable candidates for our vacancies as they arise. Veranova respects your privacy and is committed to protecting your personal information. For more information about how your personal data is used please view our privacy notice.
