What are the responsibilities and job description for the Scientist / Scientist II, Molecular and Potency, Analytical CMC position at Verve Therapeutics?
The Position
Verve is seeking a Scientist or Scientist II within the Analytical CMC team, to interface with Process Development, Internal and External Quality Control in developing, implementing, and transferring molecular and cell biology-based methods to characterize mRNA, gRNA and LNP-encapsulated gRNA and mRNA. This individual will be interfacing with a cross-functional team to design, develop and support phase- appropriate qualification of analytical methods to enable Verve’s growing gene editing pipeline.
Job Responsibilities
- Develop, optimize, and execute analytical methods intended for a variety of purposes, including release and stability testing, product characterization, high throughput analysis, and characterization of complex raw materials.
- Improve existing cell-based assays with a focus on improving robustness, reproducibility, and accuracy.
- Collaborate across multiple cross-functional teams to perform experiments and summarize work in presentations and technical reports.
- Author, review, and approve protocols, SOPs, technical reports, and sections of regulatory submissions.
- Perform laboratory experiments while providing leadership and mentorship to junior scientific team members.
- Continuously monitor the literature to identify gaps in existing methods and mobilize Verve resources to complete gap analysis.
- Act as an advisor to provide routine guidance to both the internal team and contract testing laboratories (CTL) to resolve technical problems.
- Review analytical data and provide feedback to both external and internal teams. Assist in continuous improvement activities.
- Develop and apply molecular biological methods, immunoassays, and other state of the art technologies to analyze and characterize cell and gene products.
- Analyze, track, and trend data to monitor analytical assays and ensure consistency in assay performance.
- Maintain detailed documentation of experiments in ELN system Experience automating lab procedures is highly desirable.
- Other duties as assigned.
Qualifications
M.S. in Biochemistry, Molecular Biology and / or related life sciences field with strong scientific background and 4-7 years’ relevant experience or PhD and 0-2 years relevant experience .
M.S. in Biochemistry, Molecular Biology and / or related life sciences field with strong scientific background and 7 years’ relevant experience or PhD and 2 years relevant experience .
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