What are the responsibilities and job description for the Senior Associate Scientist / Scientist I, Protein Science position at Vividion Therapeutics, Inc.?
Description
*Note: exact level depending on experience*
Company Overview
Vividion is a next generation biotechnology company based in San Diego that is leveraging its proprietary chemical proteomics platform to conduct proteome-wide footprinting of drug-protein interactions with unprecedented breadth and precision. Our technology allows us to screen, identify and optimize novel drugs that selectively bind virtually any protein, including proteins previously considered “undruggable”. Our pipeline and emerging programs reflect a matured and productive platform capable of delivering first in class drugs utilizing novel mechanisms of action (allosteric inhibitors, protein-protein interaction inhibitors, functional activators, degraders etc.) against undruggable targets in the oncology and immunology space.
We prize scientific excellence, creativity, team players and we are committed to continued innovation. We have worked hard to create a collaborative and dynamic work culture where your ideas and discoveries are valued and will have an impact. We are growing and there are opportunities for mentorship and career progression.
Vividion has been recognized as a Top Workplace by The San Diego Union-Tribune in 2022, 2023, and 2024.
Job Summary
The Protein Scientist will be a key contributor in a multidisciplinary environment focused on producing high-quality recombinant proteins for structural biology, assay development, and drug discovery efforts. This lab-based role requires extensive hands-on experience in recombinant protein expression in E. coli, insect cells and other mammalian cell lines, as well as expertise in purification, biochemical and biophysical characterization techniques. The ideal candidate is highly motivated, detail-oriented, and capable of independently designing and optimizing workflows to generate challenging protein targets. The successful candidate will play a pivotal role in integrating with cross-functional teams to advance research programs.
Requirements
Essential Duties and Responsibilities:
The anticipated base salary for this position ranges from $100,000 to $125,000 depending on relevant skills, competencies, experience, and education. In addition, this position is eligible for target bonus, long-term-incentives, 401k retirement savings plan with company match, and a comprehensive benefits package which includes medical, dental, vision, life, and disability insurance.
EEO & Employment Eligibility
Vividion Therapeutics, Inc. is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.
Privacy Policy
The protection of your personal information is a commitment we take seriously. For information regarding our Privacy Policy (CA candidates) please visit https://vividion.com/publication/privacy-noticeforcalifornia-candidates/.
*Note: exact level depending on experience*
Company Overview
Vividion is a next generation biotechnology company based in San Diego that is leveraging its proprietary chemical proteomics platform to conduct proteome-wide footprinting of drug-protein interactions with unprecedented breadth and precision. Our technology allows us to screen, identify and optimize novel drugs that selectively bind virtually any protein, including proteins previously considered “undruggable”. Our pipeline and emerging programs reflect a matured and productive platform capable of delivering first in class drugs utilizing novel mechanisms of action (allosteric inhibitors, protein-protein interaction inhibitors, functional activators, degraders etc.) against undruggable targets in the oncology and immunology space.
We prize scientific excellence, creativity, team players and we are committed to continued innovation. We have worked hard to create a collaborative and dynamic work culture where your ideas and discoveries are valued and will have an impact. We are growing and there are opportunities for mentorship and career progression.
Vividion has been recognized as a Top Workplace by The San Diego Union-Tribune in 2022, 2023, and 2024.
Job Summary
The Protein Scientist will be a key contributor in a multidisciplinary environment focused on producing high-quality recombinant proteins for structural biology, assay development, and drug discovery efforts. This lab-based role requires extensive hands-on experience in recombinant protein expression in E. coli, insect cells and other mammalian cell lines, as well as expertise in purification, biochemical and biophysical characterization techniques. The ideal candidate is highly motivated, detail-oriented, and capable of independently designing and optimizing workflows to generate challenging protein targets. The successful candidate will play a pivotal role in integrating with cross-functional teams to advance research programs.
Requirements
Essential Duties and Responsibilities:
- Design and optimize DNA constructs and expression systems in E. coli and insect cells for high-yield recombinant protein production.
- Execute and refine purification strategies utilizing FPLC (ÄKTA systems), affinity chromatography, ion exchange, and size exclusion chromatography (SEC).
- Characterize protein quality using analytical and biophysical techniques such as thermal shift assays, analytical SEC, and intact TOF-MS.
- Support early discovery with biochemical assay development and delivery of high-quality reagents for structure-based design and screening.
- Develop and maintain SOPs, improve workflows, and contribute to the scalability of internal protein production capabilities.
- Ensure lab operations, equipment maintenance, and compliance with best practices, while fostering a culture of continuous improvement.
- Ph.D. with 1–3 years OR B.S./M.S. with 6-8 years of relevant industry experience in Biochemistry, Molecular Biology, Structural Biology, or related field.
- Proven expertise in heterologous protein expression (E. coli and insect cells) and construct design.
- Strong hands-on experience with AKTA purification systems and multiple chromatography techniques.
- Proficiency in analytical and biophysical techniques for assessing protein quality, stability, and structural integrity.
- Strong organizational, documentation, and problem-solving skills; ability to manage multiple tasks in a fast-paced environment.
- Effective communicator and collaborative team player with a continuous learning mindset.
- Experience of automation workflows for high-throughput protein production.
The anticipated base salary for this position ranges from $100,000 to $125,000 depending on relevant skills, competencies, experience, and education. In addition, this position is eligible for target bonus, long-term-incentives, 401k retirement savings plan with company match, and a comprehensive benefits package which includes medical, dental, vision, life, and disability insurance.
EEO & Employment Eligibility
Vividion Therapeutics, Inc. is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.
Privacy Policy
The protection of your personal information is a commitment we take seriously. For information regarding our Privacy Policy (CA candidates) please visit https://vividion.com/publication/privacy-noticeforcalifornia-candidates/.
Salary : $100,000 - $125,000
