What are the responsibilities and job description for the Co-op, Preclinical and Translational Biology (PTB) position at Vor Bio Co-ops?
We create shielded stem cell transplants that enable targeted therapies to attack only cancer cells
Every year, thousands of patients with Acute Myeloid Leukemia (AML) and other blood cancers relapse post-transplant with no safe and effective treatment options. Vor Bio's approach provides the first opportunity to deliver potentially curative treatments post-transplant.
Our novel platform creates a shielded stem cell transplant that is designed to enable multiple modalities and therapies, including Antibody Drug Conjugates (ADCs) and Chimeric Antigen Receptor T (CAR-T) cells, which could potentially be effective against the tumor, but are toxic to normal cells. Vor's genetically engineered transplant provides a protective shield to the healthy cells and thereby allows the cancer cells to be specifically targeted for destruction.
By shielding healthy cells, Vor Bio is aiming to potentially cure Acute Myeloid Leukemia (AML) and other blood cancers. Come be a part of a passionate team striving to collaboratively develop a groundbreaking approach to cancer treatment, one of medicine's greatest challenges.
What we value in our fellow Voracians
Passion : Enthusiastically driving our science toward innovative medicines
Fellowship : Fostering genuine bonds of collaboration and mentorship
Humility : Acting selflessly by putting the collective mission first
Who we are looking for :
Vor Bio is seeking a highly motivated co-op in Preclinical and Translational Biology (PTB) department. The candidate will be integral to developing and executing proof-of concept pharmacology experiments to demonstrate protection of eHSCs from CAR-Ts using cell-based assays and flow cytometry.
Key areas of responsibility :
- Routinely perform cell culture of primary hematopoietic stem cells (HSCs), human cell lines and CAR-Ts
- Routinely perform gene editing on cell HSCs
- In vitro differentiation of HSCs into myeloid lineages
- Perform flow cytometry based cellular assay and cytokine release assay
- Perform live cell imaging assays
- Perform sanger sequencing
- Process cells and tissues from xeno-transplanted animals
- Help perform depletion of RBCs from peripheral blood
- Maintain a clear, detailed laboratory notebook to document all experiments and findings
- Present results to internal team
- Collaborate within a team environment to perform experiments
- Comply with best safety practices
Preferred Qualifications :
Minimum Qualifications :
LI-DNI
