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Principal Scientist

Vortex Biotechnology Corporation
Boulder, CO Full Time
POSTED ON 2/28/2025
AVAILABLE BEFORE 5/25/2025

About Vortex Biotechnology (VBT)

Vortex Biotechnology is at the cutting edge of cancer drug development, pioneering novel anticancer agents targeting RNA degradation and protein translation. Our CEO, a former Director of two NCI-designated CancerCenters, brings invaluable expertise in drug discovery and clinical trials. With a dedicated scientific board of renowned scientists and clinicians, VBT is poised for remarkable breakthroughs in cancer treatment. Based within the University of Colorado Boulder’s Molecular Cellular Developmental Biology Department, our labs operate in close collaboration with the University of Colorado Anschutz Medical Campus.

Position : Principal Scientist

We are seeking a driven and experienced Principal Scientist to lead key research initiatives and shape the future of cancer therapeutics. In this pivotal role, you will lead the design and execution of experiments to evaluate novel anticancer compounds, develop biophysical and biologic assays, and oversee laboratory operations. You will collaborate closely with research teams at the University of Colorado Boulder and Anschutz Medical Campus, and drive innovation through partnerships with contract research

organizations.

Key Responsibilities :

  • Lead research projects focused on anticancer drug discovery and development
  • Design and optimize both biophysical and biologic assays to evaluate compound efficacy
  • Conduct detailed analyses of experimental data and present findings to scientific teams
  • Collaborate closely with researchers at the University of Colorado and other key partners
  • Mentor and guide lab staff in experimental techniques and daily operations
  • Manage laboratory and tissue culture space, ensuring a well-maintained and effective research environment
  • Represent VBT in scientific discussions, presenting research findings to disease-focused groups and the broader scientific community

Qualifications :

  • PhD in Biochemistry, Biophysics, Cellular Biology, or related field
  • Expertise in molecular biology techniques, including RNA isolation, CRISPR / Cas9, PCR, and cloning
  • Experience with protein chemistry techniques such as Western blotting, immunoprecipitation, and protein purification
  • Strong background in biophysical assays for target evaluation
  • Expertise in mammalian cell culture, including normal and malignant cells
  • Comfortable collaborating across functions with diverse scientific teams
  • Knowledge of drug discovery processes is a plus, but industry experience is not required
  • Must be based in Colorado (Denver / Boulder area preferred)
  • Why Vortex Biotechnology?

  • Competitive salary and benefits
  • Opportunity to make an impact in cancer research
  • Work in a collaborative and dynamic environment with top-tier scientists
  • Close ties to the University of Colorado Boulder and Anschutz Medical Campus
  • Vortex Biotechnology is an equal-opportunity employer. We are committed to fostering a diverse and inclusive workforce, and we encourage applications from all qualified individuals.

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