What are the responsibilities and job description for the Discovery Synthesis and Purification Co-op (Fall 2025) position at Wave Life Sciences?
About Wave:
Wave Life Sciences is a biotechnology company focused on unlocking the broad potential of RNA medicines to transform human health. Our RNA medicines platform, PRISM, combines multiple modalities, chemistry innovation and deep insights in human genetics to deliver scientific breakthroughs that treat both rare and prevalent disorders. Our toolkit of RNA-targeting modalities includes editing, splicing, RNA interference and antisense silencing, providing us with unmatched capabilities for designing and sustainably delivering candidates that optimally address disease biology. Our diversified pipeline includes clinical programs in Duchenne muscular dystrophy, Alpha-1 antitrypsin deficiency and Huntington’s disease, as well as a preclinical program in obesity. Driven by the calling to “Reimagine Possible”, we are leading the charge toward a world in which human potential is no longer hindered by the burden of disease.
Overview:
Wave Life Sciences seeks a highly motivated co-op student to join its team of scientists in Lexington, Massachusetts. This co-op student will gain exposure to areas of oligonucleotide synthesis, formulation, purification, and analysis. The co-op will be trained in a variety of laboratory techniques and instrumentation, making this an excellent learning opportunity for future entrance into industry or academia. This is an ideal position for any student with strong organizational skills and attention to detail who thrives in a team-oriented, fast-paced and multi-disciplinary biotech environment. Completion of coursework in organic chemistry, biochemistry, analytical chemistry with laboratory experience is preferred.
Position Responsibilities:
- Perform downstream processing of oligonucleotides synthesized at various scales, utilizing various purification modalities, but specifically Anion Exchange (AEX) chromatography and size exclusion chromatography (SEC).
- Learn the AKTA Unicorn software to assist in developing new methods/gradients
- Characterize compounds using analytical instrumentation i.e., UV, pH, UPLC and LC-MS
- Operate and maintain lab equipment such as synthesizers, ÄKTA purifiers, UPLC, LC-MS, Nanodrop, and other analytical instrumentation
- Maintain timely, detailed written and electronic records of experimental protocols and data in accordance with company policy
- Potential to learn synthesis of oligonucleotides on the MM12, MM192 and AKTA synthesis systems if timing allows
Skills and Competencies
- Strict adherence to lab safety and personal protective equipment policies
- Effective and timely communication skills both interdepartmentally and with vested stakeholders, including presenting scientific data
- Attention to detail and well organized
- An inquisitive student with a positive attitude with a desire to succeed and promote change to improve efficiencies
