What are the responsibilities and job description for the Oligonucleotide Analytical Chemistry Process Development Co-op (Fall 2025) position at Wave Life Sciences?
About Wave:
Wave Life Sciences is a biotechnology company focused on unlocking the broad potential of RNA medicines to transform human health. Our RNA medicines platform, PRISM, combines multiple modalities, chemistry innovation and deep insights in human genetics to deliver scientific breakthroughs that treat both rare and prevalent disorders. Our toolkit of RNA-targeting modalities includes editing, splicing, RNA interference and antisense silencing, providing us with unmatched capabilities for designing and sustainably delivering candidates that optimally address disease biology. Our diversified pipeline includes clinical programs in Duchenne muscular dystrophy, Alpha-1 antitrypsin deficiency and Huntington’s disease, as well as a preclinical program in obesity. Driven by the calling to “Reimagine Possible”, we are leading the charge toward a world in which human potential is no longer hindered by the burden of disease.
Scope:
Wave Life Sciences USA, an oligonucleotide therapeutics company, seeks a highly motivated co-op student to join its Process Development team in Lexington, Massachusetts. The co-op will gain exposure to oligonucleotide synthesis, analytical methods for analysis, and formulations. Co-ops will be trained in a variety of laboratory techniques and instrumentation that are used throughout the pharmaceutical and biotech industry. This is an ideal position for any student, including those looking for their first co-op. The candidate should have strong organizational skills, attention to detail, and thrive in a team-oriented and fast-paced environment. Analytical chemistry or biochemistry laboratory experience is preferred.
Responsibilities
- Prepare buffer and samples for analysis
- Perform analytical QC of oligonucleotides by UV, endotoxin, osmolality, pH, LC, and LC-MS
- Assist with various solubility and stability studies
- Assist with method development activities and data analysis using a variety of software platforms
- Assist with management of oligonucleotide inventory
- Assist with maintenance and troubleshooting of lab equipment such as LC and LC-MS instrumentation
- Document experiments in an electronic notebook
Skills and Competencies
- Strict adherence to lab safety protocols including PPE
- Effective communication skills and ability to present experimental results within a small team
