What are the responsibilities and job description for the Research Associate II/Senior Research Associate, Biology position at Work In Biotech?
About Us
ARTBIO is re-defining cancer care by developing a new class of radioligand therapies (RLT) which harness the power of 212Pb and deliver it directly to the tumors. Targeted RLT is one of the fastest growing areas of oncology research and investment. The foundational technology, termed AlphaDirect, was born out of elegant research by our scientific founders, Roy Larsen and Øyvind Bruland, inventors of XofigoTM. ARTBIO is leveraging this groundbreaking science and expediting novel Drug Discovery targets which broadly exploit the unmet medical need and opportunity in revolutionizing cancer care. Supported by a committed investment board including Omega Funds, F-Prime Capital, Radforsk and Third Rock Ventures, ARTBIO has built a highly experienced, multi-disciplinary team of drug-hunters and developers. For more information on our strategy and emerging pipeline, please visit www.artbio.com and follow-us on LinkedIn.
Summary
As an emerging, global biotech with locations in Boston, Massachusetts, Basel, Switzerland, London, England and Oslo, Norway, we take advantage of diverse scientific depth and insights which makes ARTBIO a unique place to work. We are driven by a desire to do better for cancer patients, lowering the burden of toleration and safety while at the same time raising the bar on clinical efficacy and duration.
This opportunity is for an individual who strives to innovate, is never satisfied with routine, and has a strong heart for ARTBIO’s mission. A self-starter and innovator, you will be part of a cross-function team to lead key programs from our internal and partnered Discovery portfolio as well as support the build of the Early Discovery Biology disciplines at ARTBIO-Cambridge.
Responsibilities
· Develop and perform cell-based studies to support identification and validation of novel targets as well as the advancement of drug discovery projects from hit discovery through to development candidate selection
· Demonstrate proficiency and efficiency with mammalian cell culture, balancing simultaneous cell-based experiments, cell line engineering (CRISPR-Cas9, transfection, lentivirus generation and transduction), and routine maintenance culture of multiple cell lines
· Execute specimen preparation, staining, sample acquisition, analysis, and troubleshooting for flow cytometry
· Interrogate cell signaling pathways using western blotting, qPCR, RNAseq
· Develop plate-based assays to inform functional target engagement of ligands emerging from screening campaign (ELISA, complementation assays, etc)
· Independent experimental design, analysis, and presentation of data
· Analysis of literature to inform experimental design and assay development
· Multi-task and collaborate effectively with scientists and research associates across multiple teams to accomplish goals on tight timelines. Ability to navigate in a start-up environment and adapt in the ‘unknown’
· Maintain compliance with lab documentation to enable collaboration among multinational project teams
Qualifications
· BA/MA in Biology or related discipline, with 2-5 years of industrial experience, or equivalent
· Background in cancer biology with experience and demonstrated success using cell biology techniques to enable discovery biology
· Strong technical skills in mammalian cell culture are required; proficiency and independence with core techniques such as Western blotting, CRISPR, flow cytometry, phenotypic assays are also essential
· Experience in development, optimization and execution of quantitative cellular assays to support small molecule drug discovery from hit confirmation through lead optimization
· Previous experience with plate-based complementation assays is preferred
· Excellent organizational, communication, multi-tasking/time-management and collaboration skills
· Outstanding problem-solver, driven by innovative approaches, and comfortable working in a fast-paced startup environment
· Focus on the “we” rather than the “me”
· Driven by patients, passionate about our company culture, inclusive and respectful of all colleagues
