Demo

Sr/Principal Scientist, Medicinal Chemistry

Work In Biotech
San Diego, CA Full Time
POSTED ON 3/4/2025
AVAILABLE BEFORE 6/4/2025

Our client, ArCHitect Therapeutics, is hiring a talented Medicinal Chemist to join their team!

About the Company - ArCHitect therapeutics was recently founded to explore completely new, highly coveted chemical space for addressing challenging molecular targets (expand the “druggable universe”) using a combination of bleeding-edge C-H activation technologies (from Prof. Jin-Quan Yu laboratory) and activity-based-protein-profiling (from Prof. Ben Cravatt laboratory).

Job Description - We are looking for highly motivated and creative medicinal chemists to build our chemistry platform that will facilitate hit identification for novel molecular targets and rapidly translate our lead molecules from pre-clinical stage to exploratory testing in human patients.

Key Responsibilities Will Include :

  • Develop our novel chemical libraries. Design, prioritize, and implement synthetic strategies to drive library synthesis internally and at CRO.
  • Serve as chemistry team leader for hit-to-lead projects. Collaborate with in-house teams of biologist, computational chemists to drive synthetic and medicinal chemistry efforts to meet aggressive timelines.
  • Participate in decision-making processes within project teams by actively engaging in scientific and technical discussions.
  • Communicate project status, issues, results and timelines to various management and key stakeholders in an effective manner, both in writing and verbally.
  • Promote a group culture of collaboration, inclusion, and innovation.
  • The individual will lead from bench to develop synthetic route and prepare analogs for our novel chemical libraries.

Required Skills

  • Hands on synthetic organic chemistry skills are required, ideally with experience in state of art technologies such as electrochemistry, photoredox chemistry and CH activation chemistry. Experience with scale-up and process chemistry is a bonus.
  • Experienced with the design, planning and execution of multistep synthesis and purification of target compounds to expand chemical space. Experience with high throughput library synthesis is a bonus.
  • Fundamental medicinal chemistry skills : e.g., an ability to design high quality compounds considering available SAR and structure data.
  • Expertise with analytical characterization using multiple methods, such as LC-MS, HPLC, prep-HPLC, NMR for routine synthetic compounds.
  • Able to clearly communicate results in formal and informal settings.
  • Ability to work both collaboratively and independently in a fast-paced environment.
  • Willingness to partner with CROs to enable timely delivery of target compounds.
  • Qualifications :

  • Ph.D. in organic or medicinal chemistry or a related field with 4 years of experience in
  • the biopharmaceutical industry

  • Demonstrated record of problem-solving in organic chemistry and medicinal chemistry
  • Demonstrated impact on multiple hit-to-lead programs.
  • Excellent verbal, written, and interpersonal communication skills.
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