Senior Scientist Antibody/Protein Engineering

The Opportunity:

IntegerBio, a start-up biotech based in the biotech corridor of Montgomery County, Maryland, just outside Washington, DC, is building a world-class scientific team. Our company has launched with several promising assets that have been incubated and licensed by our seed funder. Led by a team of industry veterans, weve set our sights on harnessing the emerging science of immunovirology and creating a future free from viral illness.

The Job: Protein Engineering and Antibody Discovery capabilities are key to effectively growing our pipeline and bringing new molecules to the clinic. The successful Senior Scientist will bring strong technical skills, meaningful industry experience, a collaborative approach to cutting-edge scientific research and motivation to make a meaningful impact addressing unmet medical needs. As a member of our growing scientific team, the successful candidate will have the opportunity to be part of building our company.

Job Title: Senior Scientist, Antibody/Protein Engineering

Primary responsibilities include:

• Cloning, production and purification of engineered proteins
• Assay development and biophysical characterization of novel therapeutic proteins.
• Develop and execute developability analysis for lead proteins.
• Support external development and manufacturing teams to aid in progressing molecules to the clinic.
• Develop processes and assays to discover, generate and characterize antibodies against selected target antigens
• Execute strategies for antibody optimization efforts employing advanced molecular biology, biochemistry, cell biology techniques, protein analytics and modeling bioinformatics.
• Humanization, affinity maturation, and Fc engineering of novel antibodies to meet program targets.
• Stability engineering of antibodies.
• This role will collaborate with cross functional teams to discover and optimize novel therapeutic leads. Understanding disease biology in the context of antibody structure-function relationship is important.

Requirements:

• PhD in Molecular Biology, Protein Engineering, Biochemistry or other relevant fields with 3 years of postdoctoral experience.
• Experience and expertise in therapeutic antibody discovery and engineering with a strong publication record.
• Strong hands-on molecular biology experience is required.
• Experience in antibody expression and purification.
• Experience in mentoring, training and managing others
• Expertise in display technologies and combinatory library design is a plus.

FLSA Classification Exempt

Salary Range Senior Scientist: $100,800 - $166,462

IntegerBio is an equal opportunity employer, and all qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state, or local laws.