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Associate Scientist, Immunology

Xilio Therapeutics
Waltham, MA Full Time
POSTED ON 2/23/2025
AVAILABLE BEFORE 4/23/2025

Associate Scientist, Immunology

Xilio Therapeutics is a clinical-stage biotechnology company discovering and developing tumor-activated immuno-oncology (I-O) therapies with the goal of significantly improving outcomes for people living with cancer without the systemic side effects of current I-O treatments. The company is using its proprietary platform to advance a pipeline of novel, tumor-activated clinical and preclinical I-O molecules that are designed to optimize the therapeutic index by localizing anti-tumor activity within the tumor microenvironment. Learn more by visiting www.xiliotx.com and follow us on LinkedIn (Xilio Therapeutics, Inc.).

SUMMARY: 

Xilio is searching for an Associate Scientist to join the Immunology group and help enable our exciting immuno-oncology pipeline. This opening serves as an excellent opportunity to contribute to novel therapies that have the potential to help cancer patients, while developing technical skills in a trailblazing IO-focused biotech.

The position will be based in Waltham, Massachusetts, and reports to an immunology group lead.

Job Responsibilities:

  • Work closely with colleagues in immunology, cell pharmacology, and the broader research organization to support Xilio’s discovery and development programs.
  • Develop cell-based in vitro assays to assess the effect of therapeutics on immune function using primary immune cells.
  • Design, develop, qualify, and perform assays, analyze data with the appropriate statistical analyses.  Interpret and present results.
  • Work as an integrated member of the research team to generate data supportive of ongoing drug discovery efforts.
  • Contribute to key project team decisions and translational studies for development stage assets.
  • Continue to expand internal capabilities and technologies through internal collaboration and awareness of external developments.
  • Aid in management and organization of primary cell banks.
  • Capture detailed experimental information in electronic lab notebook (ELN) entries.
  • Regular participation and presentation of data and analyses at Immunology team, department meetings, project teams and other settings.

Skills, Qualifications, and Requirements:

  • BA with 3 years of post-graduate biotech/ pharma experience or MS in biology or related subject with 2 years post-graduate biotech/ pharma experience.
  • Experience with primary mammalian cell culture, immune cell differentiation, and aseptic technique is desired.
  • Familiarity with the development and execution of immunological in vitro assays is necessary.
  • Experience with ELISA, MSD, proliferation, T cell activation, and cytotoxicity is desired.
  • Experience with multi-color flow cytometry required.
  • Goal oriented, organized, capable of working on multiple projects, and able to execute to timelines that meet company goals.
  • Willing to learn new techniques and skills.
  • Work well in a cross-functional team environment, both independently as well as be willing to help others.
  • Excellent verbal and written communication skills.

Diversity, Equity and Inclusion

At Xilio Therapeutics, we foster a culture of equity, diversity and inclusion.  We consider all qualified applicants without regard to race, color, sex, gender identity or expression, sexual orientation, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, or any other characteristic protected under applicable law.  We will make reasonable accommodations, absent undue hardship, for qualified individuals with known disabilities. If you are an individual with a disability who requires an accommodation with the hiring process or to perform any essential functions of the position for which you are applying, please reach out to careers@xiliotx.com.

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