What are the responsibilities and job description for the Principal Scientist Biology (Oncology, Radiopharma, Radiotherapeutics ) position at Z-Alpha Therapeutics?
Z-Alpha Therapeutics is a pharmaceutical company dedicated to the discovery and development of radiotherapeutics targeting key biological pathways for solid tumors.The company has a revolutionary technology platform in the next generation of alpha particle therapy with potential to be a more targeted therapy, increasing efficacy and limiting toxicity compared to competitors in the radiotherapeutics space. The company has a world-class team of scientists with decades of experience and foundational intellectual property that enables the potential to bring multiple drug candidates into the clinic.
Job Summary
As a Principal Scientist in Biology with project management responsibilities, you will lead scientific initiatives and oversee project execution for Z-Alpha’s radiopharmaceutical programs. This role requires the ability to design experiments that support drug discovery and development. In addition to scientific leadership, you will manage cross-functional projects, ensuring alignment of research activities with overall program objectives and timelines.
Key Responsibilities:
Scientific Leadership: Conceptualize, design, and execute innovative functional assays for target validation and drug lead selection for radiopharmaceutical candidates.
Project Management: Lead and manage project workflows, coordinating activities across biology and chemistry teams. Ensure projects are completed on time and within scope.
Experimentation: Independently design and conduct cell-based and biochemical assays to generate high-quality, actionable data.
Analytical Development: Optimize and troubleshoot analytical assays, ensuring technical robustness and consistency with program needs.
Data Analysis & Reporting: Analyze complex datasets, interpret experimental outcomes, and present findings at project team and company-wide meetings.
Collaboration & Communication: Act as a liaison between cross-functional teams, external collaborators, and vendors to ensure smooth project execution.
Documentation: Maintain meticulous records of experiments, ensuring data integrity, reproducibility, and adherence to regulatory standards.
Mentorship: Provide scientific guidance and mentorship to junior team members, fostering a collaborative and innovative research environment.
Leadership: Establish and manage laboratory infrastructure and standard operation process.
Radiation Safety: Conduct radioligand assays in strict adherence to radiation safety protocols, ensuring a safe laboratory environment.
Required Qualifications:
Ph.D. in Biology, Oncology, or a related discipline with a strong focus on drug discovery.
5 years of experience in oncology or drug discovery within biotech or pharmaceutical research.
Demonstrated success in leading cross-functional projects in a biotech or pharmaceutical setting.
Extensive expertise in molecular and cell biology techniques including cell culture, flow cytometry, ELISA, western blotting, qPCR, and single-cell cloning.
Strong proficiency in project management tools, along with software like GraphPad Prism, FlowJo, Excel, and PowerPoint.
Highly organized, with strong time-management skills and the ability to adapt to rapidly changing project landscapes.
Collaborative team player with the ability to work independently and manage competing priorities effectively.
Excellent communication and leadership skills
Preferred Skills:
Experience in targeted radiotherapies, radiopharmaceutical development, or nuclear medicine.
