Scientist I/II, Immunology

Benefits:

• 401(k)
• Bonus based on performance
• Competitive salary
• Dental insurance
• Health insurance
• Paid time off
• Parental leave
• Stock options plan
• Vision insurance

Zag Bios vision is to develop more precise, potent medicines for immune-mediated diseases. Zag Bio is pioneering engineered antibody therapies targeted directly to the thymus, with the goal of generating central tolerance. Our technology platform is inspired by the work of co-founder Diane Mathis of Harvard Medical School; additional co-founders include Alan Crane (Polaris Partners), Jo Viney (Seismic Therapeutic), and John Kulman (Zag Bio). Zag Bio is a stealth stage biotech company, poised for growth in line with our ambition to transform the treatment of immune-mediated diseases.

We are seeking a motivated immunologist with expertise in the execution of in vivo models of autoimmune and inflammatory disease to support of advancement of the companys novel therapeutics platform for autoimmune disease. This role will require a high level of collaboration with colleagues on the therapeutic and platform development teams.

RESPONSIBILITIES:

In this role, you will report to the Senior Director of Immunology and play a vital role in the companys efforts to progress novel thymus-directed therapeutics from discovery to IND. You will apply your creativity and foundational background in immunology to:

• Formulate hypotheses, design and implement immunological assays and models, and evaluate results to elucidate therapeutic mechanism of action.
• Serve as the subject matter expert for murine pharmacology models; develop and execute project plans as part of a collaborative cross-functional team.
• Prepare and interpret scientific data to present to Leadership, in team and company meetings.
• Support, train, coach and mentor the lab team.
• Author research reports and relevant sections of regulatory documents to support first-in-human studies and contribute to intellectual property filings.
• Document research activities and findings in electronic laboratory notebook and reagent registries in keeping with the highest industry standards.

REQUIREMENTS:

• Sci I: PhD w/ 0-2 years of post-doc research experience or non-PhDs w/ 2 years of relevant experience at the Principal Associate Scientist Level
• Sci II: PhD w/ 2 years of post-doc research experience or non-PhDs with 2 years at the Scientist I level
• Demonstrated experience leveraging preclinical models of autoimmune and inflammatory disease to uncover novel mechanisms-of-action related to T cell and/or Treg cell biology
• Experience in isolating and characterizing immune cells ex vivo using multiparametric approaches such as immunophenotyping, functional assays, genomics profiling, etc.
• Ability to effectively manage multiple projects in a fast-paced environment.
• Excellent communication and interpersonal skills, and the ability to thrive in a dynamic cross-functional environment.

PREFERRED EXPERIENCE:

• Expertise in inflammatory bowel disease research is highly desirable

Zag Bio values the diversity of our workforce and maintains a deeply respectful, values-driven working environment. We are committed to equal employment opportunities and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation, or any characteristic protected under applicable law.

We are not accepting unsolicited resumes from employment agencies for any employment opportunities at this time.