What are the responsibilities and job description for the Senior Scientist/Principal Scientist Renal Biology/ Therapeutic Discovery position at Zoetis, Inc?
Role Description
Job Description: Renal Biology / Therapeutic Discovery Scientist
Level: Senior Scientist/Principal Scientist
Position Overview
We are seeking a Renal Disease Biology / Therapeutics Discovery Scientist to drive research and development efforts in chronic kidney disease therapeutics in cats and dogs. This role involves investigating renal disease pathophysiology, identifying novel therapeutic and biomarker targets, and developing new therapeutic strategies for kidney disorders. The ideal candidate will have expertise in renal pathophysiology, molecular mechanisms of kidney diseases, and translational drug discovery.
Key Responsibilities
- Conduct mechanistic research on renal diseases, including chronic kidney disease (CKD), and acute kidney injury (AKI).
- Design and execute in vitro and in vivo models to study renal function, injury, and repair mechanisms.
- Apply in vitro (cell-based, organoid) and in vivo (genetically modified, inducible disease models) systems for target validation and therapeutic evaluation.
- Identify and validate novel therapeutic targets using genomics, proteomics, and functional screening approaches.
- Conduct high-throughput screening (HTS) and assay development for target modulation and lead compound characterization.
- Working with other cross-functional teams, develop and assess small molecules, biologics and other novel therapies for renal disorders in cats and dogs.
- Collaborate with cross-functional teams, including medicinal chemists, protein engineers, pharmacologists, clinicians, and regulatory specialists, to advance drug development programs.
- Analyze and interpret experimental data, prepare technical reports, and contribute to regulatory submissions.
- Stay up to date with emerging research in renal pathobiology, drug discovery, and precision medicine.
Qualifications & Skills
- PhD, DVM/PhD, or equivalent in renal physiology, molecular biology, pharmacology, biomedical sciences, or a related field. Masters degree with extensive experience will also be considered.
- Strong expertise in renal cell biology, kidney disease mechanisms, and therapeutic development.
- Experience with cell-based assays, organoid models, omics technologies (genomics, transcriptomics, proteomics), and bioinformatics.
- Hands-on experience with CRISPR gene editing, RNA-based therapeutics, or high-throughput screening is a plus.
- Strong communication and teamwork skills, with experience in cross-disciplinary collaborations.
Preferred/Desirable Experience
- Prior experience (>2 years) in biotech, pharmaceutical R&D, or translational medicine is desirable.
- Hand on experience in fibrosis biology, inflammation, or renal regenerative medicine.
- Track record of publications and/or patents in the renal biology/therapeutics area
- Board certification in nephrology.
Opportunities & Impact
This role provides an exciting opportunity to lead cutting-edge research in canine and feline renal disease biology and drug discovery, working in a dynamic and collaborative environment. The scientist will play a key role in discovery and advancing novel treatments improving outcomes for companion animals with kidney disorders.
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Zoetis will consider any candidate for whom an Agency has submitted an unsolicited resume to have been referred by the Agency free of any charges or fees. This includes any Agency that is an approved/engaged vendor but does not have the appropriate approvals to be engaged on a search.
Zoetis is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status or any other protected classification. Disabled individuals are given an equal opportunity to use our online application system. We offer reasonable accommodations as an alternative if requested by an individual with a disability. Please contact Zoetis Colleague Services at zoetiscolleagueservices@zoetis.com to request an accommodation. Zoetis also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must possess or obtain authorization to work in the US for Zoetis. Zoetis retains sole and exclusive discretion to pursue sponsorship for the acquisition or maintenance of nonimmigrant status and employment eligibility, considering factors such as availability of qualified US workers. Individuals requiring sponsorship must disclose this fact. Please note that Zoetis seeks information related to job applications from candidates for jobs in the U.S. solely via the following: (1) our company website at www.Zoetis.com/careers site, or (2) via email to/from addresses using only the Zoetis domain of "@zoetis.com". In addition, Zoetis does not use Google Hangout for any recruitment related activities. Any solicitation or request for information related to job applications with Zoetis via any other means and/or utilizing email addresses with any other domain should be disregarded. In addition, Zoetis will never ask candidates to make any type of personal financial investment related to gaining employment with Zoetis.
