Senior Regional Sales Director (East)

Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.

This leadership role will manage a team of Account Specialists dedicated to enabling account readiness and product adoption. This role will balance field leadership responsibilities with director customer engagement and cross functional strategic planning as we build Denali’s commercial organization. As part of an emerging biopharma company, the ideal candidate will thrive in a resource efficient environment, balance strategic vision with tactical execution, and demonstrate a clear passion for patient-focused execution and team collaboration. 

Key Accountabilities / Core Job Responsibilities: 

Regional Leadership & Field Execution: 

• Attract and build a top-performing team of ETV Account Specialists 

• Lead, mentor and retain a rare disease field team to drive individual growth and team success including annual goal setting, growth planning, adherence to company policies, maintain training compliance and provide ongoing feedback on growth, development and areas of improvement 

• Act as a key thought partner to commercial leadership in building our US Go-to-Market strategy 

• Develop and implement regional sales strategies aligned with national objectives to achieve or exceed patient and community impact 

• Personally engage with key stakeholders, including healthcare providers and institutions to drive business results 

• Work with Account Specialists to develop customized strategies for each key account based on their specific needs and priorities 

• Analyze regional market trends, sales data, and customer insights to identify opportunities and challenges 

• Foster a culture of accountability, collaboration, and innovation, centered around community and patient-centric impact 

• Maintain a deep understanding of the Hunter syndrome and MPS therapy area, competitive landscape, and regional market access dynamics. 

Regional Payer Engagement: 

• Build and maintain relationships with regional payer decision-makers and influencers to optimize market access for the rare disease portfolio 

• Actively manage key regional payer relationships to drive access strategy and support reimbursement 

• Collaborate with internal Market Access and Pricing teams to execute regional payer strategies and resolve coverage challenges. 

• Communicate payer trends, formulary updates, and reimbursement policies to internal teams and Account Specialists to ensure actionable execution 

Cross-Functional Collaboration: 

• Collaborate with senior leadership to define and implement a strategic, community-centric launch strategy to enable appropriate patient adoption to maximize patient benefit 

• Partner with internal stakeholders, including Marketing, Market Access, Medical Affairs, and Patient Support teams, to ensure seamless execution of patient-centric solutions 

• Collaborate with Brand team to address skill gaps and ensure continuous improvement of the field force 

• Align regional strategies with national priorities and provide insights to senior leadership to inform strategy adjustments, including quarterly business reviews with cross functional leadership team to review business performance 

Qualifications: 

• Bachelor’s degree in business, life sciences, or related field; advanced degree (e.g., MBA, PharmD) preferred 

• Minimum of 12 years of sales experience including 10 years of pharmaceutical or biotech experience, and at least 5 years in sales leadership roles 

• Strong track record of building and leading high-performing teams with the ability to balance individual contribution and team leadership 

• Demonstrated experience in rare disease or complex therapies, with a clear passion for patient-centricity and customer-experience 

• Proven experience engaging with regional payers, including developing and executing payer access strategies 

• Exceptional strategic thinking, analytical, and problem-solving skills 

• Ability to communicate effectively and influence both internal and external stakeholders 

• Willingness to travel ~50% within the assigned region. 

This compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.This compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.
 

Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.