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Director, Program Management

Xilio Therapeutics
Waltham, MA Full Time
POSTED ON 1/6/2025
AVAILABLE BEFORE 3/6/2025

Director, Program Management

Xilio Therapeutics is a clinical-stage biotechnology company discovering and developing tumor-activated immuno-oncology (I-O) therapies with the goal of significantly improving outcomes for people living with cancer without the systemic side effects of current I-O treatments. The company is using its proprietary platform to advance a pipeline of novel, tumor-activated clinical and preclinical I-O molecules that are designed to optimize their therapeutic index by localizing anti-tumor activity within the tumor microenvironment, including tumor-activated cytokines and antibodies (including bispecifics) and immune cell engagers (including tumor-activated cell engagers and tumor-activated effector-enhanced cell engagers). Learn more by visiting www.xiliotx.com and follow us on LinkedIn (Xilio Therapeutics, Inc.)

SUMMARY: 

Reporting to the SVP, Corporate Development and Program Leadership, the new position of Director, Program Management will be an essential part of supporting Xilio’s pre-clinical programs, clinical programs and CMC planning. Vital to the success of this role is effective program management that enables efficient and quality cross-functional execution of programs, fully owned and partnered. On occasion the person in this role may also be a supportive partner to the Senior Vice President pertaining to alliance management and/or business development activities.

This is a hybrid position, based in Waltham, MA, which offers an exciting opportunity to join a dynamic, small public biotech company dedicated to bringing potentially transformative therapies to cancer patients.

Job Responsibilities:

Provide program management expertise to Xilio programs, IND-enabling stage through late-clinical development stage.

  • Lead cross-functional program teams to execute the aligned program strategy.
  • Manage, monitor, track and communicate cross-functional program timelines, deliverables, budgets, agenda trackers, critical path, and cross program dashboards.
  • Develop agendas, document key discussion points and decisions, and distribute information as appropriate to key stakeholders.
  • Support integration, coordination and communication between alliance management, business development and program management activities as needed.
  • Support CMC planning and budgeting as part of overall program strategy and execution.
  • Proactively identify potential issues or risks proactively, and diplomatically collaborate with others to plan effective mitigation strategies.
  • Monitor issues through resolution and support communication to key stakeholders, ensuring they are informed of outcomes and program implications.
  • Proactively address and remove barriers to program progress, keeping leadership informed of critical considerations (e.g., resources, performance).
  • With the SVP’s guidance and support, resolve complex issues and competing priorities that may impact achievement of goals.
  • Enthusiastically play lead role and when organizing and coordinating work behind the scenes.

Skills, Qualifications, and Requirements:

  • BS required, ideally in a scientific/engineering discipline. Advanced degree preferred.
  • 7-10 years of related work experience in the life sciences industry, with 5-7 years of demonstrated program management experience working with cross-functional teams.
  • Biotech or biopharma experience required, with pre-commercial oncology experience strongly preferred
  • Strong knowledge of IND-enabling and early clinical stage development functional planning and interdependencies of relevant functions including manufacturing within the life sciences industry.
  • Experienced in working across multiple scientific and business areas of an organization, including stakeholders at all levels of the business up to the Executive Committee
  • Experienced in managing shifting responsibilities in a dynamic, cross-functional teamwork environment.  Ability to adapt to changes to project plans, and to quickly embrace and implement new strategies and tactics to accommodate these changes.
  • Excellent oral and written communication skills including ability to synthesize, analyze, prioritize, and distill complex information into clear and succinct summaries and recommendations.
  • Prior success in building sustainable relationships with internal and external stakeholders through engendering trust and collaborative behaviors.
  • PMP, or equivalent certification, preferred. 

Diversity, Equity and Inclusion

At Xilio Therapeutics, we foster a culture of equity, diversity and inclusion.  We consider all qualified applicants without regard to race, color, sex, gender identity or expression, sexual orientation, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, or any other characteristic protected under applicable law.  We will make reasonable accommodations, absent undue hardship, for qualified individuals with known disabilities. If you are an individual with a disability who requires accommodation with the hiring process or to perform any essential functions of the position for which you are applying, please reach out to careers@xiliotx.com.

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