What are the responsibilities and job description for the Scientist, Process Development position at 4314 AstraZeneca Pharmaceuticals LP Company?
We are seeking a highly motived, data-driven researcher to join our Process Development (PD) team as a Scientist. The successful candidate should have a knowledge of basic immunology principles, bioprocess development, and cGMP manufacturing. The candidate should also have experience in primary cell culture (T cells preferred), in different formats including flasks and bags. This role will support the development of a clinical manufacturing process of engineered T cells with patient-derived neo-antigen specific TCRs. The candidate will also be part of a team involved in implementing technology and participating in technology transfer to the clinical setting.
You Will:
- Execution of process development studies to develop, optimize, scale-up and transfer cGMP manufacturing processes.
- Perform cell culture of T cells in multiple formats including flasks, bags, and bioreactors.
- Collaborate within the project team to interpret study results and contribute to technical discussions for subsequent study design.
- Prepare and review experimental proposals, technical reports, SOPs and manufacturing batch records.
- Work collaboratively within PD group and cross-functionally with other groups to meet Tech Ops organization goals.
- Other responsibilities as assigned.
You Have:
- MS degree in Immunology, Cell Biology, Molecular biology, Bioengineering, or relevant degrees with 2 years relevant industry experience or BS degree with 3 years relevant industry experience.
- Experience in technical development of cell and gene therapy or biologics in early and late development setting.
- Hands-on experience in cell and gene therapy, specifically in T cells is highly desirable.
- Experience in Flow Cytometry is highly desired.
- Knowledge of cGMP manufacturing and regulations and practical experience in GMP operations is highly desirable.
- Knowledge of QbD, DOE and appropriate statistical analysis for process development
- Ability to think critically, analytically and have demonstrated troubleshooting and problem-solving skills based on deductive reasoning.
The annual base salary for this position ranges from $87,200 to $130,800. However, base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles).
Our Benefits:
A qualified retirement program [401(k) plan]
Paid vacation, holidays, and paid leaves
Health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment.
#celltherapy #LI-Onsite
Date Posted
23-Apr-2025Closing Date
29-Apr-2025Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.Salary : $87,200 - $130,800
