What are the responsibilities and job description for the Associate Scientist (Immunology) position at Aethon Therapeutics?
WHO WE ARE
Aethon Therapeutics creates neoantigens by design, to transform cancer treatments into cures. Aethon’s novel anti-drug-peptide conjugate/MHC antibodies, engineered using the company’s proprietary HapImmune™ platform, are designed to be used in combination with targeted covalent inhibitors (TCI) of RAS, EGFR, and other oncogenic driver mutations, to mount immune attacks to selectively kill residual cancer cells, including drug-resistant “persister” cells. Aethon unites immunotherapy and small moelcule targeted therapy to expand the power and promise of both approaches for people living with cancer. For more information, visit www.aethontx.com.
Aethon is funded by Apple Tree Partners (ATP), a leader in life sciences venture capital, with $2.65 billion in committed capital
POSITION SUMMARY
We are seeking an ambitious, curious, and detail-oriented Associate Scientist to join Aethon’s growing team. Working closely with our other R&D scientists, you will help drive drug discovery and development efforts by designing and conducting experiments.
This is an exciting opportunity to work with, and learn from, multidisciplinary teams in a small, fast-paced biotechnology company. The successful candidate is able to work effectively in a team-oriented environment and is accustomed to delivering robust high-quality data on a timeline.
Key Responsibilities:
- Perform flow cytometry, cytokine release, and cytotoxicity experiments to evaluate immunological properties of T cell-engaging antibodies.
- Isolate and culture primary immune cells for in vitro and in vivo assays.
- Independently manage multiple mammalian cell lines and develop cell-culture-based protocols.
- Engineer cell lines through techniques such as CRISPR, transfection and transduction to support target validation & assay development.
- Communicate experimental plans and results to the leadership team and ensure meticulous electronic lab notebook documentation of results and protocols.
- On-site work only, no hybrid or remote option.
Qualifications:
- M.S. in Immunology, Cancer Biology, Molecular Biology, or a related field with at least 3 years of industry experience, OR
- B.S. in Immunology, Cancer Biology, Molecular Biology, or a related field with at least 5 years of industry experience.
- Expertise in isolating, culturing, engineering, and profiling cell lines and primary human or murine immune cells.
- Proficiency in multi-parameter flow cytometry, cell sorting, cytokine release assays, and gene expression analysis, including data analysis (e.g., FlowJo, GraphPad Prism, Excel, R or related programs).
- Experience performing immune cell-mediated cytotoxicity assays (e.g., Incucyte analysis) preferred.
- Familiarity with in vivo models (e.g., CDX and PDX tumor models) including dosing and necropsy is a plus.
- Strong organizational skills with the ability to manage multiple experiments simultaneously.
- Excellent communication skills, both written and verbal, with the ability to work well in a team environment.
BENEFITS
We provide a vibrant startup environment where every employee contributes to our culture and science. We offer a generous total rewards plan that includes competitive salary, stock options, and benefits. The salary range for this role is $100,000 – $120,000 annually. Actual salaries depend on a variety of factors, including experience, specialty and education.
Salary : $100,000 - $120,000