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Principal Scientist / Associate Director, Peptide Chemistry

Aizen Therapeutics
San Diego, CA Full Time
POSTED ON 3/8/2025
AVAILABLE BEFORE 6/6/2025

Title : Principal Scientist / Associate Director, Peptide Chemistry

Reports to : VP, Drug Discovery

Candidate

You are passionate about the company’s mission and a self-starter with an inextinguishable fire to compete and succeed. You thrive in an environment that requires crisp judgment, pragmatic decision-making, rapid course-corrections, and comfort with market ambiguity. You discharge your duties within a culture of mutual team respect, high performance, humility, and humor.

Candidate Responsibilities :

  • Perform molecular docking simulations for protein-ligand and protein-protein interactions to identify peptide-based drug candidates
  • Design, oversee synthesize and characterize D-peptides to drive SAR in supporting of drug discovery pipeline
  • Lead chemically modified analogs, linker chemistry, bioconjugation, purification, analytical and biophysical assessments.
  • Serves as an in-house D-peptide chemistry expert from discovery to CMC activities
  • Manage CRO operations to ensure D-peptide moieties meet project needs
  • Present data at scientific conferences and publish data in scientific journals aligned to company objectives
  • Serve as an example of teamwork and collaboration with adherence the company Team Operating Agreement

Candidate Skills and Experience

  • MS or PhD in Organic Chemistry, Biochemistry, Biophysics, Chemical Biology or related field with 6-15 years of experience in the biotech / biopharmaceutical industry
  • Deep experience in peptide (linear, cyclic, bicyclic etc.) chemistry and understanding multi-step organic synthesis is required. Hands-on experience with manual and automated systems for solid-phase synthesis of peptides is desired
  • Strong experience of peptide structure and associated biophysical techniques to assess peptide structure, stability, formulation and behavior in solution
  • Expertise in bioconjugation, half-life extension (PK), labeling chemistry, metabolic stability for peptides, especially those containing non-canonical amino acid
  • Good track record of leading the design & optimization of therapeutic peptides from hit validation to clinical candidate nomination is required
  • Experience in the discovery & development of peptide drug conjugation (PDC) or / and peptide radioligands is highly desirable
  • Experience and productivity in a multi-disciplinary team involving working with peptide CRO, external partners and collaborators
  • Strong record of innovation and productivity as a researcher, as exemplified by publications, grants, and / or patents
  • Proficiency with Python and shell scripting in developing protein design
  • Knowledge of contemporary computational protein design methods (AlphaFold2, RoseTTAFold)
  • Experience with molecular docking software (e.g. RosetttaDock, AutoDock, HADDOCK) to guide structure-based peptide drug discovery
  • Excellent oral and written communication skills
  • Entrepreneurial spirit, self-starter with proper balance of scientific creativity and disciplined execution
  • Location : This position is based in San Diego

    Compensation : Competitive base salary, stock options, and a benefits package including flexible PTO and first-class medical coverage.

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