Senior Director, Nonclinical Science

Our mission is to develop therapies that empower the immune system to combat neurodegeneration and our team is focused on developing treatments for some of the most challenging diseases facing our society. We are supported in this mission by experienced and accomplished scientists and clinicians, a novel portfolio of programs, leading healthcare investors, and pharma company partners, who share in our commitment to bettering the lives of patients and realizing a world where we make brain disorders history 

The Senior Director of Nonclinical Science will provide scientific leadership and strategic oversight in Nonclinical evaluations of Alector pipeline programs. The successful candidate will work in close partnership with Research and Development teams to facilitate seamless execution.

• Lead and supervise the Toxicology and BioAnalytical teams
• Provide strategic guidance on Nonclinical evaluations of pipeline programs. Design, execute Nonclinical studies and interpret study results together with the Toxicology team to advance programs.
• Oversee the preparation, review and approval of Nonclinical Regulatory documents and collaborate with the Toxicology and Regulatory teams for interactions with Health Authorities
• Supervise the BioAnalytical team for PK/PD/ADA assay development to support clinical programs, nonclinical programs and early stage research programs.
• Manage Nonclinical budget, FTE and other internal and external resources effectively to ensure program timelines, goals and priorities are met
• Establish and maintain close partnership with key collaborators across the organization to drive programs forward, contribute to a team culture that promotes ownership, collabration and perseverance.

• PhD in Toxicology or related scientific field, with at least 15 years of post-training experience in academia, biotech or pharma. Industry experience in drug discovery and development required
• Demonstrated leadership and expertise in non-clinical safety and a broad understanding of toxicology/pathology, bioanalytical, ADME, regulatory and clinical pharmacology.
• Proven ability to lead and collaborate on multi-function project teams, providing scientific and strategic direction to advance drug candidates from preclinical stage into clinical trials.
• Desire to work in a fast-paced environment with can-do attitude.
• Exceptional critical thinking and decision making skills
• Exceptional oral presentation and written communication skills

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At Alector, our vision is bold, people are our priority, and our values are at the core of everything we do. Our dynamic and flexible environment encourages our teams to experiment, take ownership of decisions, and question convention to solve complex problems. We value shared wins, perseverance, and a growth mindset, which drives us forward, together.  

Among the things you'll discover at Alector from your very first day are our committed and driven colleagues, a bold company vision, and new, modern offices designed to inspire innovation and collaboration in South San Francisco, right at the heart of Biotech Bay. Our benefits are thoughtfully designed around Alectorians and their loved ones and include flexible hybrid work options, competitive compensation, and comprehensive and unique benefits that enhance your health and well-being. Come join us! 

We believe that hard-working teams include people from a wide variety of backgrounds and experiences who can challenge each other’s assumptions with fresh perspectives and bring creative ideas to the table. We are committed to building an open, diverse, and inclusive environment for all employees. We do not discriminate on the basis of race, religion, color, national origin, sex, gender, sexual orientation, age, marital status, veteran status, or disability status, or any other characteristics protected under applicable federal, state, or local laws.  

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, perform essential job functions, and receive other benefits and privileges of employment. Please contact us to request accommodation. 

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Salary : $262,080 - $283,466