What are the responsibilities and job description for the Research Associate - Image-based Assay Developer position at Allen Institute?
Research Associate - Image-based Assay Developer
The mission of the Allen Institute is to unlock the complexities of bioscience and advance our knowledge to improve human health. Using an open science, multi-scale, team-oriented approach, the Allen Institute focuses on accelerating foundational research, developing standards and models, and cultivating new ideas to make a broad, transformational impact on science.
The mission of the Allen Institute for Cell Science is to create multi-scale visual models of cell organization, dynamics, and activities. Our approach encompasses large scale data collection, observation, theory, and predictions to understand cellular behavior in normal and pathological contexts. As a division within the Allen Institute, the Allen Institute for Cell Science uses a team-oriented approach, focusing on accelerating foundational research, developing standards and models, and cultivating new ideas to make a transformational impact on science.
The goal is to develop scalable, quantitative image-based assays of cell organization, activity, and function, and to generate initial data and analyses of these assays. This Research Associate I would contribute to developing robust cell-based assays of key cellular activities amenable to scale-up and integration into live-cell high-throughput microscopy pipelines. The role includes cell culturing of undifferentiated hiPS cells and fluorescence microscopy-based imaging of hiPSC and hiPSC undergoing mesodermal-directed differentiation including support of imaging automation and pipeline image acquisition. The role also includes assisting in cell biological quality control of gene-edited hiPS cell lines generated by the institute using western blotting, immunofluorescence, live-cell microscopy, and general development of cell-based assays. This role requires cross-team interaction with the Institute's technical and programmatic teams to achieve the Institute's matrixed, programmatic objectives.
The Allen Institute believes that team science significantly benefits from the participation of diverse voices, experiences and backgrounds. High-quality science can only be produced when it includes different perspectives. We are committed to increasing diversity across every team and encourage people from all backgrounds to apply for this role.
Essential Functions
- Assist in developing robust protocols and reproducible image-based assays of cell organization, dynamics, activities, and function
- Assist in cell culture operations for image-based assay development, working closely with other teams at the Institute
- Assist in cell biological quality control workflow for gene-edited hiPS cells
- Assist in microscope-based data collection and analysis of assay observations
- Collaborate with other teams in the institute to scale-up protocols into a high throughput microscopy pipeline
- Maintain rigorous quality control standards
- Maintain meticulous records and work closely with other scientists to coordinate complex experiments
- Adherence to SOPs, GLPs and regulatory requirements
- Contribute to the implementation of an image management system
- Coordinate with other programs in the Institute to ensure seamless integration and sharing of resources and data
Note : Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. This description reflects management's assignment of essential functions; it does not proscribe or restrict the tasks that may be assigned.
Required Education and Experience
Preferred Education and Experience
Work Environment
Physical Demands
Position Type / Expected Hours of Work
This role is currently working onsite and is expected to work onsite for the majority of working hours. The primary work location for this role is 615 Westlake Ave N., with the flexibility to work remotely on a limited basis.
Additional Comments
Annualized Salary Range
Benefits
It is the policy of the Allen Institute to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and / or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by federal, state or local law. In addition, the Allen Institute will provide reasonable accommodations for qualified individuals with disabilities.
Salary : $52,400 - $64,150
