What are the responsibilities and job description for the Senior Research Associate, Pharmacology position at Arcus Biosciences?
Senior Research Associate - Pharmacology
Summary
The Pharmacology team is seeking a highly motivated in vivo biologist to work closely with colleagues to discover and develop new therapies in oncology and inflammation therapeutic areas. The successful applicant will contribute to the multidisciplinary research team at Arcus. This will entail designing and executing studies, interacting closely with cross-functional groups, including biology and chemistry to establish efficacy/PK/PD relationship for the preclinical therapeutic candidates.
Responsibilities
The Pharmacology team is seeking a highly motivated in vivo biologist to work closely with colleagues to discover and develop new therapies in oncology and inflammation therapeutic areas. The successful applicant will contribute to the multidisciplinary research team at Arcus. This will entail designing and executing studies, interacting closely with cross-functional groups, including biology and chemistry to establish efficacy/PK/PD relationship for the preclinical therapeutic candidates.
Responsibilities
- Design and execute in vivo studies with small molecule / antibody-based therapeutics in disease models of oncology and immunology. Activities include cell inoculation, dosing, bleeding, monitoring of disease progression, sample collection for ex vivo assays and maintaining study documentation.
- Perform pharmacokinetic and pharmacodynamic studies.
- Perform xenograft, syngeneic and orthotopic tumor studies to test efficacy, pharmacology, and mechanism of action of anticancer therapeutics.
- Execute both acute and chronic rodent immunology models
- Research and establish new animal models, as well as troubleshooting challenges of early development.
- Partners with counterparts to plan, coordinate, and monitor the timely execution and completion of various research projects.
- Oversees the maintenance of accurate, comprehensible, and current laboratory notebooks.
Qualifications
- A minimum of 4 years of demonstrated experience in rodent model development and testing novel therapeutics in both oncology and immunology and a high school diploma or higher education.
- Expertise in handling mice and rats, including intravenous, intraperitoneal, and oral gavage administration.
- Proficient in blood collection (cardiac, RO) and tissue collection/necropsy
- Experience in surgical technique a plus
- Experience with data capturing and analysis software (i.e. electronic notebook, StudyLog, PRISM, Excel).
- Ability to focus and deliver on time-sensitive objectives
- Comfort with rapidly shifting goals as well as organizational change and evolution
This role is based at our Hayward, CA location. The anticipated salary range for fully qualified candidates applying for this position is $95,000 - $130,000 USD annually. This salary range is an estimate of what we reasonably expect to pay for this posted position. The actual salary may vary based on various factors including, without limitation, individual education, experience, tenure, skills and abilities, internal equity and alignment with market data. In addition to a competitive market-based salary, Arcus offers the opportunity to participate in stock programs, a performance-based bonus, and a comprehensive benefits package. Additional information about our total rewards program can be found here: https://arcusbio.com/careers.
Arcus Biosciences is an Equal Opportunity Employer and prohibits discrimination and harassment of any kind. Arcus is committed to the principle of equal employment opportunity for all employees and does not discriminate based on race, religion, color, sex, gender identify, sexual orientation, age, non-disqualifying physical or mental disability, national origin, veteran status or any other legally protected status. EOE/AA/Vets
PHYSICAL REQUIREMENTS: • Frequently stand, walk, twist, bend, stoop, squat, grasp lightly, use fine manipulation, grasp forcefully, perform desk-based computer tasks, use telephone, write by hand, lift, carry, push and pull objects weighing over 40 pounds. • Occasionally sit, kneel, crawl, reach and work above shoulders, sort and file paperwork or parts. • Rarely climb, scrub, sweep, mop, chop and mix or operate hand and foot controls. • Must have correctible vision to perform duties of the job. • Ability to bend, squat, kneel, stand, reach above shoulder level, and move on hard surfaces for up to eight hours. • Ability to lift heavy objects, possibly weighing up to 50 pounds. • Position may require repetitive motion. WORKING CONDITIONS: • May require working near blood borne pathogens. • May require work in an environment where animals are used for teaching and research. • Position may at times require the employee to work with or be in areas where hazardous materials and/or infectious diseases are present. • Employee must perform tasks that require the use of personal protective equipment, such as safety glasses and shoes, protective clothing and gloves, and possibly a respirator. • May require extended or unusual work hours based on research requirements and business needs. *Consistent with its obligations under the law, the company will provide reasonable accommodation to any employee with a disability who requires accommodation to perform the essential functions of his or her job.
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Salary : $95,000 - $130,000
