What are the responsibilities and job description for the Senior Scientist - High Throughput Production Biologics Engineering position at AstraZeneca?
Senior Scientist - High Throughput Production Biologics Engineering
Location: Waltham, MA (Relocating to Kendall Square/Cambridge in 2026)
Transform Ideas into Life-Changing Medicines
Do you have a passion for science and a drive to create impactful therapies? AstraZeneca, a leader in biopharmaceutical innovation, is seeking a highly motivated Senior Scientist to join our Biologics Engineering Group and advance our high-throughput production and screening capabilities for biologics.
About AstraZeneca
At AstraZeneca, we put patients first and strive to turn bold ideas into life-changing medicines. Our collaborative culture fosters innovation and empowers individuals to contribute to groundbreaking solutions in oncology, respiratory diseases, cardiovascular health, and more.
About Our Waltham, MA Campus
Located just outside Boston, our Waltham site is a hub of scientific excellence and innovation. Offering a range of modern amenities, our campus is designed to support collaboration and well-being, with:
- A fitness center and healthcare clinic
- Electric vehicle charging stations
- Full-service cafeteria and dry cleaning services
- Flexible, activity-based workspaces
In 2026, we are excited to move to Kendall Square, Cambridge, a global hub of biotech innovation.
About the Role
As a Senior Scientist in the High-Throughput Production & Screening (HTPS) team, you will be instrumental in advancing biologics discovery efforts by designing and optimizing workflows, automating processes, and collaborating across multidisciplinary teams.
Key Responsibilities:
- Design and implement high-throughput workflows for protein expression and purification, focusing on antibody-like proteins.
- Drive the production of therapeutic proteins using mammalian expression systems, automation, and robotics.
- Conduct and analyze biochemical, biophysical, and functional profiling of antibodies and recombinant antibody fragments.
- Collaborate with therapeutic area scientists to ensure efficient project progress.
- Optimize workflows and resolve technical challenges.
Qualifications
Education & Experience:
- PhD in Biotechnology, Molecular Biology, Biochemistry, or a related field.
- Master’s degree with 3 years of relevant experience in antibody engineering or protein characterization.
- Bachelor’s degree with 5 years of relevant experience.
Required Skills:
- Proficiency in molecular and cell biology techniques (e.g., cloning, transfection).
- Hands-on experience with protein expression, purification, and antibody formats.
- Expertise in CHO and HEK293 cell culture techniques.
- Experience with automation platforms (e.g., Hamilton liquid handlers).
- Strong organizational and time-management skills.
Desired Skills:
- Experience in antibody discovery and advanced purification techniques.
- Familiarity with multicolor flow cytometry platforms (e.g., iQue, FlowJo).
- Coding knowledge (Python, Jupyter Notebook).
- Understanding of Design of Experiments (DOE) for workflow optimization.
Why AstraZeneca?
We are committed to delivering life-changing medicines and redefining possibilities in biopharma. By embracing diverse perspectives, pioneering science, and bold ideas, AstraZeneca fosters a culture of innovation and collaboration to transform patient outcomes worldwide.
What We Offer
- Competitive base salary, annual bonus, and long-term incentives.
- Generous paid time off.
- Comprehensive benefits package.
Diversity and Inclusion at AstraZeneca
We are committed to building an inclusive and diverse workplace. We welcome applicants of all backgrounds and provide reasonable accommodations for candidates with disabilities during the application process and employment.
Ready to Make an Impact?
Join AstraZeneca and take your career to the next level while contributing to life-changing therapies.
