Senior Principal Analytical Scientist - Mass Spectrometry

ATUM is seeking an experienced and highly skilled Mass Spectrometry (MS) Scientist to join our analytical team. The ideal candidate will play a key role in advancing analytical methodologies to support large molecule characterization and quality assessment of internal R&D and client projects.

The successful candidate will be an integral part of ATUM s analytical team, driving method development, troubleshooting, and robust data analysis to interrogate and/or ensure product quality and release testing.Key Responsibilities:

• Develop and optimize MS methods for qualitative and quantitative analysis, ensuring high sensitivity and reproducibility.
• Perform data acquisition, processing, and interpretation of MS datasets to support research, development, and product services.
• Develop and execute analytical MS methods, including, but not limited to:
  • Peptide mapping and liability assessment
  • Glycan Profiling
  • Reduced/Intact Mass
• Ensure appropriate maintenance of assigned equipment, conduct training, and scope process optimization with a continuous improvement mindset.
• Contribute more broadly to ATUM's analytics ecosystem, with a focus on delivering a best-in-class analytics platform for addressing client needs.
• Prepare and review technical reports, method protocols, and analytical documentation in compliance with regulatory guidelines.
• Develop custom analytical services upon request.
• Active participation/lead technical projects within the group.
• Train and mentor junior team members in analytical techniques and data analysis best practices.

Required Qualifications:

• Ph.D. in Analytical Chemistry, Biochemistry, or a related discipline with 2 years of industry experience; OR M.S. with 5 years of relevant experience.
• Extensive expertise in LC-MS method development and troubleshooting for characterization of biomolecules, including comprehensive experience with complex large molecule characterization that includes detailed liability and PTM assessment/QC of in-process and fully purified products.
• A robust practical understanding of large molecules and their respective stage-appropriate analytical methods.
• Proficiency in data analysis software (e.g., Protein Metrics, MassLynx, Xcalibur, Analyst, Chromeleon, Empower, etc.).
• Excellent problem-solving skills with the ability to design experiments, analyze data, and interpret results.
• Strong written and verbal communication skills to effectively document and present findings.

Preferred Qualifications:

• Familiarity with automation and high-throughput analytical workflows, in particular to their application with MS sample prep, data acquisition and analysis.
• An understanding of FPOP, HDX, and/or other MS techniques used to map protein surface topology, study protein dynamics and interactions.
• Ability to write scripts for developing customized methods and analyses.
• Demonstrated ability to work in a fast-paced, collaborative environment.

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