Principal Scientist - Protein Engineering & Bioassay Development

Brief DescriptionAre you an expert at cell biology and mammalian cell culture and bioassays? Deep interest in directed evolution, mutagenesis and protein engineering? Understand the importance of high throughput assays to drive exploration of biochemical space? This job is for you!Full Job DescriptionPrincipal Scientist – Protein Engineering and Bioassay DevelopmentBioLoomic’s Mission : BioLoomics is developing safer, more effective cancer medicines using Super-ADCs that increase binding & payload delivery to tumors. Traditional ADCs only deliver less than 1% of injected dose to tumors. The remainder of the therapy delivers toxic payload to healthy tissues, severely limiting the therapeutic index. Our Super-ADCs improve the tumor targeting efficiency of ADCs and have the promise to change the landscape of oncology in the next 5-10 years.Super-ADCs leverage peptide-antibody fusions that bind, cluster and bend membranes to increase ADC delivery to the surface and lysosome. As we push forward our lead molecules through preclinical animal studies, we aim to scale our design-build-test-learn platform for discovery and development of these peptides using a combination of multi-well and single-cell based high throughput screening methods. Accordingly, we are seeking a highly qualified principal scientist to oversee, drive, and scale the ‘test’ in our design-build-test-learn process to yield valuable variants of Super-ADCs.Our high-performance culture relies on recruiting top talent that display exemplary skills of judgement, curiosity, passion, courage, innovation, communication, impact, honesty and selflessness. Our tight knit team seeks to push the limits of the ADC field and disrupt the ever-growing ADC market with a platform solution that drives not only our internal clinical programs but also improves clinical programs for strategic partnerships. We aim to build a lasting great company to further strengthen the growing Boulder Biotechnology ecosystem by leveraging great scientists, great science, and hard work. Let’s revolutionize oncology therapies together!The Contribution You Will Make : BioLoomics is seeking an experienced Principal Scientist, centered on ADCs. You will be responsible for 80% benchwork, 20% leadership & strategy of the cell biology team. This position has 1 direct report in the short term with team expansion to an additional 2-4 scientists as the program develops. You will report directly to the CSO, Dr. Kurt Gish, an ADC veteran of 20 years. This role is 100% on-site, full-time with a semi-flexible work schedule, and may require light weekend work.The Impact of Your Work : Successful execution by you and your team will lead to the discovery of novel ADCs that will progress to the clinic and have the potential to become life-saving medicines for people in need. You will also play a critical role in developing other scientists and innovative technologies that fuel BioLoomics’s mission.Your Core Responsibilities : Driving strategy and process development for our high throughput Super-ADC screening platform using FACS and / or ELISA to assess membrane binding and other cell-based mechanistic features.Designing and executing with the team various mechanistic studies on our Super-ADCs using high resolution microscopy, cell line development, and other techniques.Prototyping improvements for our single-cell testing screening platform.Author and / or contribute to abstracts / manuscripts, patents, study reports, and regulatory submissions.Keeping up to date on the relevant techniques and literature related to our process and mission.The Skills & Experience That Are Required : Ph.D. with 4 years’ experience in the biotech or pharma industry with bioassay development and execution.Experience leading, developing and inspiring high performance in wet lab scientists in an industry setting.Excellent skills in mammalian cell culture, immunostaining and high throughput screening process development using FACS (FACS Aria, Accuri) and plate readers (MD SpectraMax).Strong ability to independently plan a team’s day-to-day execution and to keep management up to date with results, hurdles, and timelines.Well-developed organization, lab notebook, and verbal communication skills.Strong experience compiling and presenting data and journal articles to science-oriented audiences.Adaptability, flexibility, and passion to work in a dynamic startup environment.The Skills & Experience That Are Preferred : Programming expertise in Python.Deep structural biology knowledge.What We Offer : A collaborative and rewarding environment for cutting edge innovation of technology, therapies, and science towards a cohesive goal of making better cancer therapies.Our state-of-the-art facility is well equipped for an advance cell biologist. We have an impressive array of tools including : FACS (sorting and high throughput scanning), high throughput fluorescent microscopes, liquid handling automation, a full stack cell culture facility, and mammalian robotic cell picking.Opportunity to : (1) further develop leadership skills and participate in important corporate strategy discussion (board meetings, partnership meetings with large pharma), (2) to help drive the company’s success, and (3) to directly drive the personal growth of team members and yourself.Competitive compensation, generous PTO, moving costs, matching 401k, medical, dental, vision and generous stock options.BioLoomics is an equal opportunity employer and committed to a diverse workplace. All applicants will be considered equally without regard to race, color, ethnicity, veteran status, religion, national origin, marital status, political affiliation, age, sex, sexual orientation, disability status, membership in an organization or any other non-merit factors.#J-18808-Ljbffr