Advisor - Upstream Process Development

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Organization Overview

At Lilly, we serve an extraordinary purpose. We make a difference for people around the globe by discovering, developing and delivering medicines that help them live longer, healthier, more active lives. Not only do we deliver breakthrough medications, but you also can count on us to develop creative solutions to support communities through philanthropy and volunteerism

This position is part of the Upstream Process Development group in the Bioprocess Research and Development (BR&D) organization within Lilly Research Labs. BR&D delivers new medicines to patients through the development and commercialization of insulins, peptides, oligonucleotides, monoclonal antibodies, novel therapeutic proteins, and gene therapy systems.

The Advisor - Upstream Process Development is responsible for the development and optimization of technologies and processes to produce recombinant therapeutic proteins and genetic medicines, as well as for process control strategy development, process scale-up, and technology transfer to pilot plant and manufacturing sites.

Responsibilities

• Lead the design, execution, and interpretation of upstream experiments for processes leading to the generation of drug substance (therapeutic proteins or genetic medicines).
• Participate in and/or lead cross-functional process development teams and effectively collaborate with other groups in Bioprocess and Bioproduct Development, Discovery, TS&MS and Manufacturing.
• Support the process scale-up and tech transfer of upstream processes to manufacturing sites.
• Use mathematical methods, computer tools, and fundamental scientific and engineering principles applied to experimental designs, process development, and process understanding.
• Leading/supporting organizational strategic initiatives, evaluating and/or installing new capabilities/technologies, and leveraging internal and external influence to solve problems, improve platform productivities, and benchmark potential solutions.
• Work effectively with external parties on development projects, research collaborations and outsourcing efforts.
• Authorship of technical reports and regulatory documents.
• Lead/support implementation of organizational strategic initiatives in support of the Lily pipeline.
• Keep abreast of relevant scientific literature/new technologies/capabilities and regulatory initiatives/requirements. Lead implementation, as appropriate.
• Ensure work and team activities are aligned with all relevant Development Quality, regulatory, HSE, GLP requirements.
  
  
  

Basic Requirements

• Ph.D. in Chemical Engineering, Biological Engineering, Bioengineering, Biotechnology, Biochemistry or related field with 0-3 years of experience.
• Alternatively, skills commensurate with a PhD scientist with Upstream Process Development experience.
• General knowledge of cell culture and fermentation with an emphasis on production of recombinant proteins and genetic medicines.
• Problem solving and decision-making.
• Demonstration of scientific and people leadership skills.
• Effective oral and written communication skills.
• Must be able to work productively in an interdisciplinary team environment.
  
  
  

Additional Skills/Preferences

• General knowledge and understanding of issues associated with scaling of upstream processes, and use of statistics for data analysis.
• Hands-on experiences with mammalian bioprocess (CHO or HEK293) and with scale-down models (bench scale bioreactors).
• Experience with intensified fed-batch and/or perfusion process.
• Familiarity with process/media development for recombinant protein production, genetic medicines, or other relevant therapeutic cell culture derived modalities.
  
  
  

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is

$121,500 - $198,000

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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