Oligonucleotide Chemistry Co-op

Company Overview

Dyne Therapeutics is focused on discovering and advancing innovative life-transforming therapeutics for people living with genetically driven neuromuscular diseases. Leveraging the modularity of its FORCE™ platform, Dyne is developing targeted therapeutics that deliver to muscle and the central nervous system (CNS). Dyne has a broad pipeline for neuromuscular diseases, including clinical programs for myotonic dystrophy type 1 (DM1) and Duchenne muscular dystrophy (DMD) and preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease.

Role Summary

Dyne is seeking a co-op for the Oligonucleotide Chemistry team who is passionate about research and excited to participate in developing therapies for rare diseases with unmet needs. This student will focus on RNA therapeutics at the intersection of chemistry and biology, with a particular emphasis on synthesizing oligonucleotides (short DNA and RNA analogs) ability to turn off the expression of disease-causing genes. This work will help us enhance our growing pipeline driving innovation and accelerating development of new therapies.

This role is based in Waltham, MA without the possibility of being remote. This is a 6-month position beginning in July. 

Primary Responsibilities Include

• Perform solid phase synthesis of chemically modified oligonucleotides at various scales to support in vitro and in vivo experiments
• Perform purification of oligonucleotides to achieve high purity standards
• Perform analysis (HPLC/UPLC), and characterization (LCMS, UV, melting temperature) of oligonucleotides and their conjugates
• Multi-task across several projects
• Gather data, create compelling slides, and present findings in group meetings
• Eagerness to learn key aspects of RNA therapeutics and to synthesize oligonucleotides to support this research
  
  
  

Education And Skills Requirements

• Currently enrolled in a Bachelors, Masters, or PhD program in Biochemistry, Organic Chemistry or related fields
• Prior lab experience highly preferred
• Background/coursework in chemistry, biochemistry, organic chemistry, and analytical chemistry required
• General knowledge of DNA/RNA structure and function is a plus but not required
• Knowledge of software applications using Microsoft Office Skills (PowerPoint, Word, Excel)
• Strong communication skills and willingness to collaborate with team members
• Basic knowledge of Microsoft Word, Excel, Power Point
  
  
  

The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements. Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload.

This description is not intended to be constructed as an exhaustive list of duties, responsibilities, or requirements for the position. This position may change or assume additional duties at any time. The employee may be requested to perform different or additional duties as assigned. All Employees are expected to adhere to all company policies and act as a role model for company values.

Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.