UNIV - Post Doctoral Scholar (Research) - Department of Pathology and Laboratory

Job Description Summary The Department of Pathology and Laboratory Medicine at the Medical University of South Carolina (MUSC) invites applications for a postdoctoral researcher position in Alzheimer’s disease (AD) research. We are seeking a highly motivated and talented research scholar to study the role of cellular senescence in brain aging and AD pathogenesis. A growing body of evidence has demonstrated the implications of senescent cells in AD, and a set of senolytic drugs are being tested in clinical trials for AD treatment (https://pmc.ncbi.nlm.nih.gov/articles/PMC10168460/). However, the precise cellular and molecular mechanisms by which age associated accumulation of senescent cells in the brain affect AD pathogenesis and progression have yet to be determined. The successful candidate will utilize an array of state-of-the-art technologies and systems biology approach, including cellular & molecular biology techniques, single-cell RNA sequencing, spatial proteomics, RNAscope, neuropathology, supper-resolution confocal microscopy, and AD animal models, to delineate how senescent cells modulate neuroinflammation, AD pathology, and cognitive function in preclinical AD animal models. Entity Medical University of South Carolina (MUSC - Univ) Worker Type Employee Worker Sub-Type Regular Cost Center CC001002 COM PATH Basic Research CC Pay Rate Type Hourly Pay Grade University-00 Pay Range 0.00 - 0.00 - 0.000 Scheduled Weekly Hours 40 Work Shift Job Description Candidates should have a recent Ph.D. in neurobiology, molecular cell biology, neuroscience, or other related fields. Interested applicants should send your current CV, a cover letter describing your research interests/previous experience/future career goals, and the contact information for three references to Dr. Gavin Wang at wangy@musc.edu. Competitive salary and benefits will be commensurate with qualifications and experience. Previous experience with AD transgenic mouse models, snRNA-seq, spatial proteomics, and confocal microscopy is highly preferred. Job Duties 30% - In consultation with the PI, design and execute experiments to advance independent research projects. S/he will be responsible for planning experiments, developing new assays and experimental models as needed, trouble shooting, data analysis and interpretation, and being able to incorporate the results into manuscripts and sections of grant proposals. 25% - Perform specific assays including histological procedures, quantitative RT-PCR, immunoblotting, immunofluorescence, confocal microscopy, and flow cytometry assays. 30% - Conduct standard animal experiments, including the handle of transgenic mice, mouse intraperitoneal and tail vein injections, rodent general surgeries (specific surgical procedures can be learned and trained as needed), collecting animal brain tissues, IHC, and data analysis. 10% - Assist the PI in training and supervising graduate students, technicians, research assistants and junior lab members. 5% - Attend seminars, career development activities locally and nationally at conferences, submit abstracts and present data at local, national & international meetings, and if applicable write postdoctoral fellowship applications and grant proposals.   Minimum Experience and Training Requirements Candidates should have a Ph.D. in neuroscience, molecular cell biology, cellular neurobiology, or any other related fields. Preferred Experience & Additional Skills Expert-level intellectual input to the research objectives and data interpretation of the PI’s projects. Ability to work independently in experimental design and project execution. Good oral and written communication skills. Ability to train and supervise technicians and graduate students. Additional Job Description Physical Requirements: (Note: The following descriptions are applicable to this section: Continuous - 6-8 hours per shift; Frequent - 2-6 hours per shift; Infrequent - 0-2 hours per shift) Ability to perform job functions in an upright position. (Continuous) Ability to perform job functions in a seated position. (Continuous) Ability to perform job functions while walking/mobile. (Frequent) Ability to climb stairs. (Infrequent) Ability to work indoors. (Continuous) Ability to work in all cold temperature extremes, i.e. spot coolers. (Frequent) Ability to bend at the waist. (Frequent) Ability to twist at the waist. (Frequent) Ability to perform 'pinching' operations. (Continuous) Ability to fully use both hands/arms. (Continuous) Ability to perform repetitive motions with hands/wrists/elbows and shoulders. (Continuous) Ability to fully use both legs. (Continuous) Ability to reach in all directions. (Continuous) Possess good finger dexterity. (Continuous) Ability to maintain tactile sensory functions. (Continuous) Ability to maintain good olfactory sensory function. (Continuous) Ability to lift and carry 15 lbs., unassisted. (Frequent) Ability to lift objects, up to 15 lbs., from floor level to height of 72 inches, unassisted. (Frequent) Ability to lower objects, up to 15 lbs., from height of 72 inches to floor level, unassisted. (Frequent) Ability to push/pull objects, up to 15 lbs., unassisted. (Infrequent) Ability to lift and carry objects up to 15 lbs. a distance of five (5) floors and to outlying buildings. (Frequent) Ability to maintain 20/40 vision, corrected. (Continuous) Ability to see and recognize objects close at hand. (Continuous) Ability to see and recognize objects at a distance. (Continuous) Ability to match or discriminate between colors. (Continuous) Ability to determine distance/relationship between objects; depth perception. (Continuous) Good peripheral vision capabilities. (Continuous) Ability to maintain hearing acuity, with correction. (Continuous) Ability to perform gross motor functions with frequent fine motor movements. (Continuous) Ability to be qualified physically (by medical personnel) for respirator use, initially and annually. Ability to work alone in isolated areas, such as darkrooms. (Frequent) Additional New Requirements: Ability to obtain and maintain a valid drivers license. Computer literacy. Ability to work rotating shifts as required. Ability to work overtime as required. Ability to learn and use new processes, tools and equipment as required. If you like working with energetic enthusiastic individuals, you will enjoy your career with us! The Medical University of South Carolina is an Equal Opportunity Employer. MUSC does not discriminate on the basis of race, color, religion or belief, age, sex, national origin, gender identity, sexual orientation, disability, protected veteran status, family or parental status, or any other status protected by state laws and/or federal regulations. All qualified applicants are encouraged to apply and will receive consideration for employment based upon applicable qualifications, merit and business need. Medical University of South Carolina participates in the federal E-Verify program to confirm the identity and employment authorization of all newly hired employees. For further information about the E-Verify program, please click here: http://www.uscis.gov/e-verify/employees Thank you for wanting to be part of the Medical University of South Carolina team. Whether you want to teach the next generation of health care leaders, innovate new business models, discover the next breakthrough or provide patient care, there's a role for you that fuels your passion and takes advantage of your skills. There are career opportunities available in academics, research, hospital medicine, physician practices and support services, from patient billing to IT. As an applicant, you can search jobs for all MUSC entities as well as search by category and location. MUSC attracts more than $250 million annually in research funding, making it the biggest magnet for biomedical, extramural research dollars of all institutions of higher learning in South Carolina. The Clinical and Translational Science Award (CTSA) Program aims to advance clinical and translational science to increase the speed at which new treatments become available to patients. MUSC Health, the clinical enterprise, operates a 750 bed medical center, which includes a nationally recognized Children’s Hospital, the Ashley River Tower (cardiovascular, digestive disease, and surgical oncology), Hollings Cancer Center (one of fewer than 70 elite National Cancer Institute designated centers), a Level I Trauma Center and the Institute of Psychiatry. In addition, there are more than 100 outreach clinics, hospital/health system affiliations, and telehealth sites. U.S. News & World Report placed us among the top one percent of all American hospitals, with 11 specialties in the top 50. The MUSC Medical Center is also one of only three Magnet® designated hospitals in South Carolina.

Salary : $250