Associate Director, DMPK

Who We Are

Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science, and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.

Position Description

The Associate Director, Drug Metabolism and Pharmacokinetics position is a unique opportunity to shape the DMPK strategy and contribute to the development of innovative therapeutics. Initially, this role will function as an individual contributor, collaborating closely with external partners such as Pharma and CROs. As the company grows, this position could evolve into a leadership role with direct reports.

Responsibilities

• Strategic Leadership
• Develop and implement the DMPK strategy to support drug discovery and development programs
• Provide expert DMPK guidance and input to project teams
• Represent the DMPK function in cross-functional meetings and interactions with external stakeholders
• Stay abreast of the latest advancements in DMPK science and regulatory guidelines
• Collaboration and Outsourcing
• Effectively collaborate with CROs and other external partners to execute DMPK studies
• Manage CRO relationships, including study design, data analysis, and report writing
• Oversee the quality and timely delivery of DMPK data from external partners
• Individual Contribution
• Design and execute DMPK studies, including in vitro and in vivo experiments
• Analyze and interpret DMPK data to support drug candidate selection and development
• Author and review DMPK reports, regulatory documents, and scientific publications
  

Position Requirements

• Ph.D. in pharmacokinetics, drug metabolism, or a related field
• 8 years of experience in DMPK within the pharmaceutical or biotechnology industry
• Strong understanding of DMPK principles and their application to drug discovery and development
• Extensive experience in designing and conducting in vitro and in vivo DMPK studies
• Proven ability to analyze and interpret DMPK data to inform drug development decisions
• Excellent communication, interpersonal, and collaboration skills
• Experience in managing CROs and external partnerships
• Prior experience in writing regulatory documents is highly desirable
• Must be willing to work onsite at least 4 days a week
  
  

Nice To Have

• Experience with a variety of therapeutic modalities, including small molecules, biologics, and oligonucleotides
• Familiarity with regulatory guidelines and requirements for DMPK studies
• Experience with modeling and simulation software
  
  

The estimated base salary range for this role is $235,000 - $243,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.