What are the responsibilities and job description for the (Sr.) Director, DMPK, Orexin Program position at Centessa?
Centessa Pharmaceuticals plc (Nasdaq : CNTA) is a new kind of pharmaceutical company with a deconstructed R&D environment that prioritizes data driven decision making led by subject matter experts. Centessa is advancing a portfolio of high conviction programs with strong biological validation.
Read on to find out what you will need to succeed in this position, including skills, qualifications, and experience.
Our asset-centric model offers a unique R&D logic that has been applied by single asset companies to improve productivity. This operating model has minimal centralized infrastructure, reduced hierarchy, and exclusive focus on data driven capital allocation. Our teams are uniquely incentivized to expeditiously interrogate key scientific hypotheses. We believe the asset-centric model can lead to improved success rates for programs with greater speed and modest costs.
Position Summary :
The Director / Senior Director, DMPK will be responsible for leading the Drug Metabolism and Pharmacokinetics (DMPK) activities across the Orexin agonist portfolio, guiding the strategy and execution of DMPK studies from early discovery through clinical development for small molecule drugs. This role requires a deep understanding of pharmacokinetics, pharmacodynamics, drug metabolism, and bioanalytical methodologies.
Key Responsibilities :
- Provide strategic direction and oversight to ensure high-quality and timely delivery of DMPK data.
- Develop and implement DMPK strategies that align with Centessa’s drug discovery and development objectives.
- Collaborate within project teams and across other functional groups including pharmacology, toxicology, CMC, medicinal chemistry, and clinical.
- Oversee the design, execution and interpretation of in vitro, in vivo, and in silico DMPK studies including robust assessment of ADME properties, transporters, prediction of human PK and dose projections, PK / PD relationships and drug-drug interaction potential.
- Provide expert interpretation of DMPK data and present findings to project teams, senior management and external stakeholders.
- Responsible for reviewing BA and TK reports from non-GLP and GLP tox studies, and for conducting PK / TK analysis and preparing reports as needed.
- Prepare and review DMPK sections for regulatory submissions (IND, IB, etc) and other relevant documents for clinical development.
- Build and maintain strong relationships with CROs, consultants and other external partners to enhance DMPK resources and capabilities.
Education and Qualifications :
Work Location :
This is a remote role based in the US, with infrequent (