Demo

Scientist II

cGxPServe
MA Full Time
POSTED ON 4/26/2025
AVAILABLE BEFORE 5/22/2025

Job description :

The Biologics CMC Developability team is an integral part of the Biologics CMC Drug Product Development organization. The Biologics CMC Developability team conducts high-throughput screening of physicochemical properties of discovery-stage biologic drug candidates to identify liabilities, helping in the selection of lead candidates for pipeline advancement. We have an exciting opportunity for a motivated scientist to join the client's Biologics CMC Developability team based in Worcester, MA.

Responsibilities :

  • Conduct laboratory-based high-throughput screening and analytical, biophysical, and biochemical characterization of biologic drug candidates.
  • Perform experiments to screen physicochemical properties of biologic molecules (antibodies, bispecific antibodies, antibody drug conjugates, and genetic medicine modalities) and identify liabilities that may impact drug development.
  • Enable automation and high-throughput screening of discovery candidate molecules.
  • Execute experimental protocols, collect results, and perform data analysis independently.
  • Maintain excellent documentation of work including electronic lab notebook and protocols.
  • Prepare and deliver concise scientific presentations of experimental results.
  • Oversee maintenance of key laboratory equipment and routine laboratory operations.
  • Build strong relationships with other team members and across groups.
  • Understand and adhere to corporate standards regarding code of conduct, safety, and documentation compliance.

Requirements :

  • BS or MS in Biochemistry, Biology, Chemistry (or equivalent, e.g., Chemical Engineering, Pharmaceutical Sciences) with 3 (BS) or 1 years (MS), biopharmaceutical industry experience preferred.
  • Hands-on experience in protein biochemical and biophysical characterization. Experience with diverse biologic formats desired.
  • Detailed knowledge of protein structure, biophysical characterization, and formulation screening.
  • Experience in protein biophysical and biochemical characterization techniques, including chromatography (size-exclusion, ion exchange and hydrophobic interaction chromatography), differential scanning calorimetry & fluorimetry, dynamic light scattering, UV-VIS and fluorescence spectroscopy, imaged capillary isoelectric focusing, capillary electrophoresis, particle and viscosity measurements. Must be willing and able to learn new technologies as needed.
  • Prior experience in high-throughput automation and mass spectrometry would be beneficial.
  • Demonstrated track record of independent thinking, creativity, and scientific accomplishment.
  • Highly responsible and self-motivated. Skills to plan and conduct experiments with high quality and timely deliverables. Able to perform data analysis using MS Excel & GraphPad.
  • Team player with excellent collaboration and communication skills.
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