What are the responsibilities and job description for the Oligonucleotide Chemist position at Comrise?
OLIGONUCLEOTIDE CHEMIST
Location: Cambridge, MA (Onsite)
Salary: $90K to $100k base
PRIMARY RESPONSIBILITIES ：
- Be responsible for the day-to-day work and management of the Oligonucleotide teams in Boston
- Design and implement innovative strategies for the synthesis, purification, and scale-up of oligonucleotides
- Utilize hands-on experience to optimize synthetic routes, purification methods, and bioconjugation protocols
- Conduct analytical characterization using HPLC, LC-MS, and other analytical methods.
- Complete the goals associated with specific oligonucleotide process optimization projects.
- Develop solutions and provide recommendations as to the appropriate course of action to technical problems associated with the preparation of synthetic oligonucleotides.
- Provides documentation and validation support in execution of synthesis and/or purification process changes.
- Performs laboratory work and documentation in accordance with regulatory standards and company guidelines.
- Mentor oligo team members, providing technical guidance and expertise in oligonucleotide chemistry
EDUCATION AND EXPERIENCE：
- Minimum of a bachelor’s degree in Biochemistry, Chemistry, Molecular Biology or related discipline.
- Minimum of 5 years of industrial or academic experience in the synthesis and purification of oligonucleotides.
- Excellent understanding of the basic structure and function of DNA and RNA, including but not limited to advanced applications such as gene cloning and NGS preparation.
SKILL REQUIREMENTS：
Competence & Skills
- Experienced in high-throughput oligonucleotides synthesis, proficient in the operation of the 192&768 synthesizer, and carrying out simple instrument troubleshooting and repair.
- Proficient in multiple analytical and purification techniques for DNA/RNA oligonucleotides to ensure that the purity and quality of oligonucleotides meet experimental requirements.
- Experienced in the application of LC-MS technology for accurate qualitative and quantitative analysis of nucleotides.
- Knowledge of commonly used biomolecular analysis methods (e.g. qPCR, DNA sequencing) or relevant practical experience.
- Knowledge of the downstream application of oligonucleotides, like gene synthesis, molecular cloning, NGS, etc.
Professional Attitude
- Good scientific thinking and innovation ability, able to independently design experimental programs and promote project progress.
- Good teamwork spirit, able to communicate effectively with other researchers and solve research problems together.
- Strong willingness to learn and ability to quickly adapt to new technologies and methods.
- Welcome the challenge and extra responsibilities.
- With clear career aspiration and willing to make impact to the environment
WORKING RELATIONSHIPS
- Report to: Oligo Team Leader
- You will be working with internal oligo team, as well as downstream gene synthesis, molecular cloning and NGS team at Boston
Salary : $90,000 - $100,000
