Oligonucleotide Chemist

Take a Look at Your Future with Quintara Biosciences

·       The mission of Quintara Biosciences is to provide integrated DNA services (DNA reading, writing, editing, and making) to the life science community by creating and delivering innovative translational technologies and platforms.

·       A path towards your most rewarding career.You will be challenged to work in a results-driven, fast-paced organization; you will work with passionate professionals who strive to develop innovative products and technologies that advance the life sciences; and you will excel in an environment of respect, integrity, and fair opportunities for growth.

PRIMARY RESPONSIBILITIES ：

·       Beresponsible for the day-to-day work and management of the Oligonucleotideteams in Boston

·       Design and implement innovative strategies for the synthesis, purification, and scale-up of oligonucleotides

·       Utilize hands-on experience to optimize synthetic routes, purification methods, and bioconjugation protocols

·       Conduct analytical characterization using HPLC, LC-MS,and other analytical methods.

·       Complete the goals associated with specific oligonucleotide process optimization projects.

·       Develop solutions and providing recommendations as to the appropriate course of action to technical problems associated with the preparation of synthetic oligonucleotides.

·       Provides documentation and validation support in execution of synthesis and/or purification process changes.

·       Performs laboratory work and documentation in accordance with regulatory standards and company guidelines.

·       Mentor oligo team members, providing technical guidance and expertise in oligonucleotide chemistry

EDUCATION AND EXPERIENCE：

·       Minimum of a Master Degree in Biochemistry, Chemistry, Molecular Biology or related discipline.

·       Minimum of 5 year of industrial or academic experience in the synthesis and purification of oligonucleotides.

·       Excellent understanding of the basic structure and function of DNA and RNA, including but not limited to advanced applications such as gene cloning, NGS preparation.

SKILL REQUIREMENTS：

-      Competence & Skills

·       Experienced in high-throughput oligonucleotides synthesis, proficient in the operation of the 192&768 synthesizer, and carry out simple instrument troubleshooting and repair.

·       Proficient in multiple analytical and purification techniques for DNA/RNA oligonucleotidesto ensure that the purity and quality of oligonucleotides meeting experimental requirements.

·       Experienced in the application of LC-MS technology for accurate qualitative and quantitative analysis of nucleotides.

·       Knowledge of commonly used biomolecular analysis methods (e.g. qPCR, DNA sequencing) or relevant practical experience.

·       Knowledge of the downstream application of oligonucleotides, like gene synthesis, molecular cloning, NGS, etc.

-      Professional Attitude

·       Good scientific thinking and innovation ability, able to independently design experimental programs and promote project progress.

·       Good teamwork spirit, able to communicate effectively with other researchers and solve research problems together.

·       Strong willingness to learn and ability to quickly adapt to new technologies and methods.

·       Welcome challenge and extra responsibilities.

·       With clear career aspiration and willing to make impact to the environment

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WORKING RELATIONSHIPS

·       Report to: Oligo Team Leader

· Works with: you will be working with internal oligo team, as well as downstream gene synthesis, molecular cloning and NGS team at Boston