Research Technician - Ligon Lab

Overview

A Research Associate/Technician position is immediately available in the Brain Tumor Precision Medicine laboratory of Dr. Keith Ligon. Prior experience in laboratory research is required. The position will involve the multidisciplinary study of cancer cell biology and mechanisms of treatment resistance in adult and pediatric gliomas. The position will involve use and training in a cutting edge techniques such as functional genomics (CRISPR screening), patient-derived human models of cancer, AI/ML methods in digital pathology and spatial biology analysis, human clinical trials. tissue biomarker analysis, genomics studies, stem cell culture, and development of high throughput screening methods for functional precision medicine. Skills or ability to apply computational approaches and implementation of bioinformatics methods is desired (e.g. R programming). Developing independence and will be fostered, and opportunities for intellectual input will also be readily available. The Ligon lab environment is highly collaborative and there will be opportunities to interact with top-tier investigators and their teams in translational and basic science collaborations at the national and international level. Resarch associates also have opportunity for joint appointments at the Broad Institute, Harvard Medical School, and Brigham and Women’s Hospitals as projects require. Applicants will have excellent mentoring and training for academia and industry through projects in the lab and with external collaborators at the national and international level.

Position is available immediately.

We are seeking candidates with at least two years of availability.

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

Responsibilities

• In vitro cell culture and drug screening of human patient derived organoids/spheroids and models
• In vivo study, maintenance, and treatment of patient derived xenografts for evaluation of biology and therapeutics
• Supervised work to perform CRISPR engineering of patient models and screening
• Generation of molecular and sequencing data and extractions of DNA/RNA, single cell isolations
• Supervised use of spatial biology methods to examine tissue responses in models and patient sample.
• Presentation at internal and external meetings of work

SUPERVISORY RESPONSIBILITIES:

Research Technician

No supervisory responsibilities. Normally receives detailed instructions on all work.

Qualifications

• Undergrad degree is required preferably in molecular biology, bioengineering, biochemistry, neuroscience, or related scientific field is preferred.
• Prior experience in research is required.
• Knowledge of information and techniques related to either biology, chemistry, or medicine is preferred.
• Must have excellent communication skills (written and verbal) and be able to work with a wide variety of faculty and staff.
• Ability to analyze information and use logic to address work-related issues and problems.
• Must have attention to detail and be thorough in completing work tasks.
• Ability to work within a team environment.

KNOWLEDGE, SKILLS AND ABILITIES REQUIRED:

• Knowledge of information and techniques related to either biology, chemistry, or medicine is preferred.
• Must have excellent communication skills (written and verbal) and be able to work with a wide variety of faculty and staff.
• Ability to analyze information and use logic to address work-related issues and problems.
• Must have attention to detail and be thorough in completing work tasks.
• Ability to work within a team environment.

At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff. Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply.

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law.

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