Scientist / Senior Scientist - Oligonucleotide Chemistry

Empirico, a clinical-stage biotechnology company that combines unmatched expertise in human genetics-driven target discovery with world-class capabilities in siRNA medicines is seeking a talented chemist with experience in solid-phase oligonucleotide synthesis and analytics. This is an excellent opportunity for a highly motivated, creative scientist to be a vital member of our team.

• You will be responsible for driving the synthesis, purification, and characterization of oligonucleotides and their conjugates, and optimizing methodologies to support the development of siRNA medicines. The ideal candidate will have a strong background in organic chemistry and analytical techniques. You will be expected to –
• Independently lead discovery-scale solid phase synthesis, purification, and characterization of oligonucleotides and oligonucleotide conjugates
• Mentor junior team members, providing guidance on experimental design and data interpretation
• Analyze, interpret, and communicate synthetic and analytical results
• Present results at group meetings to senior staff
• Troubleshoot and resolve complex technical challenges to optimize current procedures
• Multitask and work on several different projects simultaneously

• This position requires a PhD in Organic Chemistry, or a Master’s degree in combination with at least one year of experience
• Experience with analytical instruments, such as NMR, LC-MS, RP-HPLC
• Desire to work in a fast-paced and dynamic environment
• 1-7 years of relevant work experience, preferably in solid phase synthesis
• Analytical or purification method development experience using RPIP-HPLC, AEX-HPLC, UV, NMR, LCMS, MALDI, and HRMS is highly desired
• Applicants must have authorization to work in the U.S.

The estimated annual base salary range for this role is $90,000 to $140,000. Individual compensation decisions will be based on various factors, such as primary work location, complexity and responsibility of role, job duties/requirements, and relevant experience and skills.  We offer a wide range of benefits including a retirement savings plan (with company match), paid vacation, holidays, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.

About Empirico: Empirico is a clinical-stage biotechnology company that discovers and develops novel medicines designed to mimic naturally-occurring genetic variants that confer beneficial effects on health and disease. Empirico’s two foundational technology platforms – the Precision Insights Platform™ for genetically-validated target discovery, and the siRCH™ platform for the discovery and development of siRNA medicines – are used separately and in tandem to enable Empirico and our collaborators from the discovery and validation of novel targets to clinically-viable therapeutics. Empirico’s exceptional internal capabilities, augmented by those of its partners, are driving the advancement of a growing and differentiated pipeline of wholly-owned and partnered programs. Empirico is headquartered in San Diego, CA with a major second site in Madison, WI.

We’re striving to build a strong culture of inclusivity, transparency and collaboration at Empirico, where our diverse and equitable workforce is empowered to contribute to our mission. We always seek the best candidate for the position and encourage you to apply even if your experience or qualifications don’t match up exactly with the job description. Empirico is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.

To All Agencies: Please do not contact any employee of Empirico about this position. All resumes submitted by agencies to any employee of Empirico via-email or in any form and by any method will be deemed the sole property of Empirico, unless such agencies were engaged by Empirico for this position and a valid agreement is in place.

Salary : $90,000 - $140,000