What are the responsibilities and job description for the VP / Head of Clinical Development position at Engine Biosciences?
Why Engine Bio?
Engine Biosciences is a venture-backed company discovering and developing impactful precision medicines by deciphering complex biology with integrated computation and experimentation, with particular depth in oncology gained over several years of substantial investment and focus. Having pinpointed many promising drug targets, tumor vulnerabilities, and biomarkers predicting patients most likely to benefit from therapies, Engine is advancing its pipeline of oncology therapeutics towards the clinic internally and with collaborators, and in other disease areas through partnerships. Engine’s team is motivated by opportunities to address significant unmet needs with more selective and effective precision medicines. For more information, please visit
We are a fast-paced, innovative company. We are excited to have passionate and talented staff join our team in California (SF Bay Area) or Singapore. We offer excellent career growth opportunities, and a chance to work closely with experienced business and scientific leaders.
Job Description :
Engine Biosciences is seeking a highly experienced and dynamic Head of Clinical Development to lead the transition of our novel oncology therapeutics from preclinical development into clinical trials. This key leadership role will be responsible for designing and executing clinical strategies, overseeing clinical operations, and ensuring the successful advancement of our programs. The ideal candidate will bring deep expertise in oncology drug development, a strong strategic mindset, and the ability to collaborate effectively across multidisciplinary teams and external partners.
Responsibilities :
- Lead the clinical development strategy and execution for Engine Biosciences’ oncology pipeline, ensuring alignment with regulatory requirements and corporate objectives.
- Oversee the design, implementation, and management of early-phase clinical trials, including protocol development, site selection, and patient recruitment strategies.
- Work cross-functionally with preclinical, regulatory, and translational science teams to optimize clinical development plans and biomarker-driven patient selection approaches.
- Serve as the primary clinical expert, interfacing with regulatory agencies (FDA, EMA, etc), key opinion leaders (KOLs), and strategic partners.
- Establish and maintain strong relationships with clinical investigators, CROs, and external collaborators to ensure high-quality clinical trial execution.
- Drive data analysis and interpretation, contributing to regulatory submissions, investor presentations, and scientific publications.
- Provide leadership and mentorship to the clinical development team, fostering a high-performance culture within a fast-paced biotech environment.
- Participate in development of clinical budgets, working with clinical operations and finance teams to budget and ensure cost-effective execution of clinical trials while maintaining high-quality and regulatory compliance.
- Contribute to strategic decision-making on portfolio prioritization, risk assessment, and long-term development planning.
- Support financing and business development efforts by effectively communicating clinical strategy, progress, and impact to investors and potential partners.
Qualifications and Experience :
Location :
California (SF Bay Area) or Singapore