What are the responsibilities and job description for the VP / Head of Clinical Operations position at Engine Biosciences?
Why Engine Bio?
Engine Biosciences is a venture-backed company discovering and developing impactful precision medicines by deciphering complex biology with integrated computation and experimentation, with particular depth in oncology gained over several years of substantial investment and focus. Having pinpointed many promising drug targets, tumor vulnerabilities, and biomarkers predicting patients most likely to benefit from therapies, Engine is advancing its pipeline of oncology therapeutics towards the clinic internally and with collaborators, and in other disease areas through partnerships. Engine’s team is motivated by opportunities to address significant unmet needs with more selective and effective precision medicines. For more information, please visit
We are a fast-paced, innovative company. We are excited to have passionate and talented staff join our team in California (SF Bay Area) or Singapore. We offer excellent career growth opportunities, and a chance to work closely with experienced business and scientific leaders.
Job Description :
Engine Biosciences is seeking a highly experienced and strategic Head of Clinical Operations to lead and oversee the execution of clinical trials for our novel oncology therapeutics. This key leadership role will be responsible for ensuring efficient, high-quality, and regulatory-compliant clinical operations from study intitiation to completion. The ideal candidate will have deep expertise in managing global clinical trials, working with CROs, and optimizing clinical operations processes in a fast-paced biotech environment.
Responsibilities :
- Develop and implement clinical operations strategies to support the successful execution of clinical trials, ensuring alignment with corporate objectives.
- Oversee end-to-end clinical trial operations, including site selection, patient recruitment, study monitoring, data management, and trial execution.
- Lead interactions with CROs, vendors, and investigators to ensure timelines, budgets, and quality standards are met, including managing contract negotiations and performance oversight.
- Collaborate closely with clinical development, regulatory, and translational science teams to align operational plans with clinical strategies, regulatory submissions, and corporate objectives.
- Ensure compliance with global regulatory requirements, GCP guidelines, and company SOPs.
- Identify and mitigate risks associated with clinical trials, proactively addressing challenges to keep programs on track.
- Drive continuous improvement in clinical operations, implementing best practices and innovative solutions to enhance trial efficiency and effectiveness.
- Build and lead a high-performing clinical operations team, fostering a culture of collaboration, accountability, and excellence.
- Develop and manage clinical trial budgets, ensuring cost-effective execution and proactive financial risk mitigation, working with clinical development and finance teams.
- Support financing and business development activities by representing the clinical operations function with investors and companies.
Qualifications and Experience :
Location :
California (SF Bay Area) or Singapore