Sr. Scientist, Biology

About Firefly Bio

Firefly specializes in Degrader Antibody Conjugates (DACs) which combine the unique strengths of ADCs with selective protein degraders. Our mission is to unlock the full potential of bioconjugates and develop medicines with long-lasting benefits for patients. We are establishing an expert team to build state-of-the-art platform capabilities for the invention and development of innovative drug conjugates. Our company culture is built on the values of Focus, Integrity, Respect and Energy. We are looking for passionate individuals committed to making an impact on the future of medicine.

Position Summary

The Sr. Scientist in Biology will be a key member of the Biology team, leading efforts to understand the mechanistic biology of oncology targets and contributing to program leadership. They will conceive, design, plan, and execute in vitro studies to evaluate novel antibody drug conjugates for applications in oncology and other areas of unmet medical need. The position is lab-facing and on-site. Title and compensation package will be based on experience and relevant skills.

Responsibilities

• Drive and execute on the design, development, and optimization of in vitro biochemical and cellular assays to evaluate novel payloads, antibodies, and ADCs (antibody drug conjugates) Oversee and contribute to the design and execution of in vitro studies for target validation
• Establish robust in-house capabilities to perform in vitro experiments with high throughput
• Contribute to the understanding of program biology and participate in new target recommendations
• Leverage cell surface target antigen biology to guide therapeutic design and identify appropriate preclinical models
• Collaborate cross-functionally with Protein Sciences and Chemistry teams
• Oversee cell line procurement, evaluation of optimal culture conditions, expansion, storage, and cell line inventory
• Actively participate in department and project team meetings
• Design and manage CRO studies where applicable to support internal efforts
  
  

Requirements And Experience

• Ph.D. with a degree in cancer, cell or molecular biology or closely related field
• 6 years of industry experience in cellular assays and drug development research
• Strong background in cancer biology and ADCs (antibody drug conjugates) including managing experiments at CROs
• Strong hands-on experience in designing and executing in vitro experiments to validate targets and treatment ideas using ADCs, mAbs, degraders or small molecules
• Expertise in target validation and cell signaling work preferred
• Experience with flow cytometry, cell culture, antigen internalization assay, cell viability and toxicity assays, Western blot analysis, ELISA, cell-based fluorescence and chemiluminescence assays, and cell line engineering
• Proven capabilities in maintenance of cell line health and longevity
• Experience with handling animal and human tissues
• Highly organized, diligent, and quality focused with excellent computer and documentation skills
• Ability to analyze, interpret, and present data in a clear manner.
• Experience with translational methods and analyses including IHC, transcriptomics, genomics and proteomics a plus
• Demonstrated success in collaborative planning and execution as a project team leader
• Creativity and problem-solving skills paired with the ability to excel in a highly collaborative environment
• Comfortable working in a dynamic and fast paced environment.
• Excellent oral and written communication and interpersonal skills
  
  

Benefits

Every team member is essential in shaping Firefly Bio’s culture and science and for our success. We offer competitive compensation packages including stock options and the opportunity to be part of ground-breaking research. Firefly Bio is an equal opportunity employer and will consider all applicants for employment. Firefly Bio does not discriminate based on race, sex, color, religion, age, national origin, marital status, disability, veteran status, genetic information, sexual orientation, gender identity or any other reason prohibited by law in provision of employment opportunities and benefits.