Contractor, Research Associate II, Biophysics

About Generate Biomedicines

Generate:Biomedicines is a new kind of therapeutics company – existing at the intersection of machine learning, biological engineering, and medicine – pioneering Generative Biology™ to create breakthrough medicines where novel therapeutics are computationally generated, instead of being discovered. The Company has built a machine learning-powered biomedicines platform with the potential to generate new drugs across a wide range of biologic modalities. This platform represents a potentially fundamental shift in what is possible in the field of biotherapeutic development.

We pursue this audacious vision because we believe in the unique and revolutionary power of generative biology to radically transform the lives of billions, with an outsized opportunity for patients in need. We are seeking collaborative, relentless problem solvers that share our passion for impact to join us!

Generate:Biomedicines was founded in 2018 by Flagship Pioneering and has received over $700 millionin funding, providing the resources to rapidly scale the organization. The Company has offices in Somerville and Andover, Massachusetts with 300 employees.

The Role:

The Protein Analytics Group is seeking a talented and self-motivated individual to support the high throughput (HTP) protein characterization effort. This person will work cross-functionally with scientists from Protein Sciences, Computational Biology, Preclinical Discovery, and Development teams, as well as external organizations to advance portfolio programs. The successful candidate will be trained to operate a wide range of analytical equipment, including analytical HPLCs and automated liquid handling robots, and will contribute to designing, optimizing, and executing state-of-the-art HTP methods. This is an exciting opportunity to be part of a fast-paced start-up environment with great culture.

This is a full time Contractor position budgeted through 2025**

Here’s how you will contribute:

• Complete training to independently execute state-of-the-art HTP methods, including but not limited to various chromatography methods (affinity, RP, HIC, IEX and SEC via FPLC, HPLC, UHPLC, UPLC, nanoUPLC), electrophoresis (r/nrCE-SDS, cIEF, SDS-PAGE, native PAGE), sizing (SEC-MALS, DLS), viscometry and particle analyses (HIAC, MFI).
• Conduct long-term developability assessment and formulation screening using a wide collection of analytical techniques. If required, perform new methodologies to stress proteins for characterizations of post-translational modifications (PTMs) of interest.
• Develop new methods to expand on the analytical workflows in-house.
• Analyze and cross-functionally communicate analytical data.
• Draft internal operational protocols and external publications.
• Cross-train colleagues within or outside the group as a subject-matter expert.

The ideal candidate will have:

MSc degree in a related field, or a BSc degree with 2 years of related experience (industry preferred). Qualified candidates with a BSc degree and<2 years of experience will be considered at the Research Associate I level. An educational background in protein chemistry, biochemistry or biophysics is strongly preferred.

Training or practical experience in: Protein characterization via chromatography (affinity, RP, HIC, IEX and SEC via FPLC, HPLC, UHPLC, UPLC, nanoUPLC), electrophoresis (r/nrCE-SDS, cIEF, SDS-PAGE, native PAGE), sizing (SEC-MALS, DLS), viscometry and particle analyses (HIAC, MFI), Protein therapeutics developability assessments, and HTP plate-based assays (eg: ELISA)

Experience in mass spectrometry and protein chemistry is a plus.

Excellent attention to detail and documentation skills.

Outstanding communication skills, transparency and respect for others.

Generate:Biomedicines is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

COVID Safety:

Generate:Biomedicines enforces a mandatory vaccination policy for COVID-19. All employees must be fully vaccinated and have received a booster. The purpose of this policy is to safeguard the health of our employees, their families, and the community at large from infectious disease that may be reduced by vaccinations. The Company will make exceptions to this policy if required by applicable law and will consider requests for an exemption from this policy due to a medical reason, or because of a sincerely held religious belief, or any other exemptions that may be recognized by applicable.

Recruitment & Staffing Agencies : Generate:Biomedicines does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Generate:Biomedicines or its employees is strictly prohibited unless contacted directly by the Company’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Generate:Biomedicines and the Company will not owe any referral or other fees with respect thereto.