What are the responsibilities and job description for the Principal Associate Scientist / Scientist, Immunology Discovery Research position at Generation Bio?
Generation Bio is seeking an energetic and highly motivated Principal Associate Scientist / Scientist to join the Immunology team within the Discovery Research group. The position will play a key role in evaluating our cell targeted lipid nanoparticle (ctLNP) delivery platform by designing, executing, and analyzing in vitro assays aimed at evaluating ctLNPs interacting with immune cells. The ideal candidate will have a strong background in cell-based assays (such as but not limited to experience isolating and maintaining primary immune cells, T cell activation/differentiation assays, and flow cytometry). Responsibilities will also include cross-functional research to enable early program development.
RESPONSIBILITIES:
- Contribute to the design, optimization and execution of assays to assess ctLNP interactions with primary immune cells
- Generate target validation / proof of concept data packages using siRNA-mediated modulation of T cell targets
- Work with Preclinical Group to screen novel ctLNPs and target biology for new platform technologies
- Perform a range of biochemical techniques such as ELISA, MSD, qPCR and flow cytometry to characterize protein and RNA expression and function
- Design experiments, analyze data and interpret results
- Summarize work in written reports and oral presentations
- Maintain accurate and up-to-date laboratory records
QUALIFICATIONS:
- Experience in the fields of immunology or cell biology (or related)
- MS with a minimum of 3 years or BS with with a minimum of 6 years of industry experience
- Demonstrated hands-on experience in primary immune cell assay development and execution is required
- Experience isolating and culturing primary T cells from human and/or mouse is essential
- Experience with T cell assays (such as T cell activation and differentiation) preferred
- Knowledge of flow cytometry and multi-color panel design strongly desired
- Experience with qPCR, western blot techniques, ELISAs, etc. a plus
- Ability to work cross functionally in a dynamic matrixed environment
- Ability to multi-task to support multiple projects across platform discovery organization
- Organized, excellent communication skills, collaborative mindset
POSITION: Full-Time, Exempt
