What are the responsibilities and job description for the Scientist, Immunology, Discovery Research position at Generation Bio?
SUMMARY:
Generation Bio is seeking an energetic and highly motivated Scientist to join the Immunology team within the Discovery Research group. The position will play a key role in development and evaluation our cell targeted lipid nanoparticle (ctLNP) delivery platform by developing and executing in vitro assays aimed at evaluating ctLNPs interacting with immune cells. The position will play a key role in evaluating our cell targeted lipid nanoparticle (ctLNP) delivery platform by designing, executing, and analyzing in vitro assays aimed at evaluating ctLNPs interacting with immune cells. The ideal candidate will have a strong background in cell based assays (such as, but not limited to immune-assays and ELISAs, experience isolating and maintaining primary immune cells, T cell activation/differentiation, and flow cytometry). Responsibilities will also include cross-functional research to enable early program development for indications in target cell types.
RESPONSIBILITIES:
- Contribute to the design, optimization and execution of assays to assess ctLNP interactions with primary immune cells
- Work with Preclinical Group to evaluate novel ctLNPs and target biologies for new platform technologies
- Perform a range of biochemical techniques such as ELISA, MSD, qPCR and flow cytometry to characterize protein and RNA expression and function.
- Design experiments, analyze data and interpret results
- Summarize work in written reports and oral presentations
- Maintain accurate and up-to-date laboratory records
QUALIFICATIONS:
- Experience in the fields of immunology or cell biology (or related)
- PhD, MS with a minimum of 6 years of related experience, or BS with a minimum of 8 years of related experience, industry experience preferred.
- Demonstrated leadership and hands on experience in primary immune cell assay development and execution
- Experience isolating and culturing primary immune cells, such as T cells and B cells from human and/or mouse required
- Experience with T cell assays (such as T cell activation and differentiation)
- Knowledge of flow cytometry and multi-color panel design strongly desired
- Experience with QPCR, western blot techniques, ELISAs, etc a plus
- Ability to work cross functionally in a dynamic matrixed environment
- Ability to multi-task to support multiple projects across platform discovery organization
- Organized, excellent communication skills, collaborative mindset
POSITION: Full-Time, Exempt
