What are the responsibilities and job description for the Research Scientist II/III, DNA Synthesis position at GenScript/ProBio?
About GenScript
GenScript Biotech Corporation (Stock Code: 1548.HK) is a global biotechnology group. Founded in 2002, GenScript has an established global presence across North America, Europe, the Greater China, and Asia Pacific. GenScript's businesses encompass four major categories based on its leading gene synthesis technology, including operation as a Life Science CRO, enzyme and synthetic biology products, biologics development and manufacturing, and cell therapy.
GenScript is committed to striving towards its vision of being the most reliable biotech company in the world to make humans and nature healthier through biotechnology.
About ProBio
ProBio proactively provides end-to-end CDMO service from drug discovery to commercialization with proactive strategies, professional solutions and efficient processes in cell and gene therapy (CGT), vaccine, biologics discovery and antibody protein drug to accelerate drug development for customers. ProBio's total cell and gene therapy solution covers CMC of plasmid and virus for IND filing as well as clinical manufacturing and commercial manufacturing. In terms of plasmid service, ProBio supports the most clinical approvals for CGT drugs including mRNA vaccines, CAR-T in China. It is also the first GMP manufacturing platform to provide in vitro transcription (IVT) template linearized plasmids for mRNA vaccines and has supported several mRNA vaccine global enterprises to obtain clinical approvals. In terms of viral vector service, ProBio has a stable and high-yield viral vector platform.
Why Join Us?
Join the #1 DNA synthesis company at the forefront of innovation, leveraging the most advanced technologies in the field. As a member of our team, you will have the opportunity to contribute to groundbreaking advancements drug discovery, biomedical research and synthetic biology. Your work will play a pivotal role in shaping transformative solutions with far-reaching applications, from next-generation therapeutics to cutting-edge diagnostics. Be part of a dynamic, visionary organization where your expertise and creativity will drive meaningful scientific progress.
Role Description:
We are seeking a highly motivated Research Scientist to join our R&D team dedicated to advancing DNA synthesis technologies. This role offers the opportunity to drive innovation in nucleic acid chemistry, oligonucleotide synthesis, and molecular biology. You will play a critical role in optimizing our solid-phase DNA synthesis platform and developing next-generation applications. Your expertise in surface chemistry, analytical techniques, and molecular biology will be integral to shaping the future of DNA synthesis technology.
Key Responsibilities:
- Design and optimize surface functionalization techniques for solid-phase oligonucleotide synthesis.
- Develop next-generation solid-phase DNA synthesis platforms and explore their applications.
- Create novel electrochemical detection assays for oligonucleotide microarrays.
- Characterize complex DNA oligo pools using advanced analytical methods.
- Select and implement techniques to evaluate surface properties and functionality.
- Contribute to nucleic acid chemistry innovations, including phosphoramidite-based and enzymatic oligonucleotide synthesis.
- Optimize all aspects of the company's DNA synthesis workflows.
- Collaborate with production teams to transfer technology, improve processes, and troubleshoot challenges.
- Perform statistical data analysis and effectively present findings to stakeholders.
Qualifications:
- PhD in Chemical Biology, Chemistry, Materials Science, Biochemistry, Bioengineering, or related biomedical fields; or MS with at least 3 years of relevant industry experience.
- Proficiency in nucleoside, nucleotide, and solid-phase oligonucleotide synthesis.
- Strong understanding of nucleic acid chemistry principles.
- Experience with electrochemistry and electrochemical detection methods (preferred).
- Familiarity with automation tools (a plus).
- Advanced molecular biology skills including PCR, qPCR, hybridization assays, and NGS techniques.
- Proven ability to work collaboratively within interdisciplinary teams.
- Goal-oriented mindset with a hands-on approach to problem-solving.
- Excellent written and verbal communication skills.
- Strong documentation practices for preparing technical reports, data summaries, and manufacturing transfer procedures.
- Self-motivated individual passionate about innovation in biotechnology.
Benefit:
- Medical Insurance/ Vision Insurance/ Dental Insurance
- 401(k) & Retirement Savings Plan (RSP)
- Short Term Disability Insurance
- New Child Leave
- Paid Time Off
- Paid Company Holidays per year
- Paid Sick Days (earned based on hours worked)
- Compassionate Leave
- Jury Duty Leave
- Float day
- Personal days
Perks:
- Free colleague meals during shift
- Onsite messages Charis
- Onsite gyms
Compensation:
Salary range: $80,000 – $110,000, depending on experience and qualifications.
GenScript USA Inc/ProBio Inc. is a proud equal opportunity/affirmative action employer committed to attracting, retaining, and maximizing the performance of a diverse and inclusive workforce. It is the Company's policy to ensure equal employment opportunity without discrimination or harassment based on race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, age, disability, national origin, marital or domestic/civil partnership status, genetic information, citizenship status, uniformed service member or veteran status, or any other characteristic protected by law.
Salary : $80,000 - $110,000
