Staff Scientist (Senior Manager), Assay & Process Development

About Glyphic:

At Glyphic Biotechnologies, we plan to create the protein revolution for which scientists and researchers have been waiting. We are developing a massively parallel, single-molecule proteome sequencing platform that will transform life science discovery and usher in a new era of insights into human biology and disease. To date, we have raised >$50M from venture partners and non-dilutive grant funding to achieve our vision of next generation proteome sequencing.

What we are looking for in you:

Glyphic is seeking a highly motivated and experienced Assay & Process Development Scientist to design, develop, and optimize assays that leverage our cutting-edge single molecule proteome sequencing platform. The ideal candidate will have a strong background in assay development, DNA & protein biochemistry, NGS, and instrumentation, and be eager to contribute to transformative advances in proteomics. The scientist will work with a cross-disciplinary team of chemists, biologists, engineers, and bio-informaticians to rapidly deliver consistent results and insights that accelerate the development cycle.

Responsibilities:

• Design, develop, and optimize assays for single molecule protein sequencing, ensuring high sensitivity, specificity, and reproducibility.
• Collaborate with cross-functional teams including chemistry, bioinformatics, engineering, and product development to integrate assay workflows with technological advancements.
• Analyze complex experimental data, generate detailed reports, and provide actionable insights to guide further development.
• Utilize statistical methods and data visualization tools to interpret assay performance and ensure rigorous quality control.
• Prepare and maintain comprehensive documentation of experimental protocols, standard operating procedures (SOPs), and results.
• Drive innovation in assay design and contribute to intellectual property development.
• Develop domain expertise in next generation protein sequencing.
  
  

Required Competencies:

• Degree in biology, chemistry, or related field, PhD preferred
• 6 years of experience in assay/process development and validation, with emphasis in proteomics, genomics, or related areas
• Comprehensive knowledge about nucleic acids biochemistry and bioconjugation
• Experience in lab methods, such as PCR, electrophoresis, cytometry, NGS library preparation, and nanopore sequencing.
• Experience with transferring manual assays onto engineering prototypes or commercial robotic platforms
• Experience in development of a commercial product, a plus
• Excellent problem-solving skills and attention to detail.
• Strong written and verbal communication skills, with the ability to document experiments clearly and collaborate effectively with multidisciplinary teams.
• Experience in data analysis software
• Experience in statistical and DOE software
• Adapts to fast-paced environments with changing priorities and responsibilities.
  
  

Benefits and Perks:

• Employee Stock Option Plan
• 100% Health Plan Coverage for Employees & Dependents (Medical, Dental, & Vision)
• Employer Retirement Contributions to 401(k)
• Generous Paid Time Off
• Paid Maternity and Paternity Leave
• Health & Wellbeing Program
• Office Snacks and Beverages
• Regular Team Bonding Activities
  
  

We are an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. Individuals seeking employment at Glyphic Biotechnologies are considered without regard to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation.

Compensation Range: $146K - $183K