Director of DMPK/Clinical Pharmacology

Job Description

Job Description

JOB SUMMARY

Under the supervision of the Executive Director DMPK / Clinical Pharmacology the candidate will lead DMPK / Clinical Pharmacology efforts on Clinical Development programs at Iambic. The candidate will setting clear objectives and overseeing design and implement Clinical Pharmacology and DMPK studies to support programs and deliver on corporate goals. Oversee For drug discovery efforts and preclinical / clinical drug development the focus will be on design and completion of ADME studies to support go / no-go decisions and guide the chemistry and biology groups. The position requires collaboration with internal and external partners to plan and execute DMPK studies. This role will support both research and clinical efforts and is based at the San Diego headquarters.

KEY RESPONSIBILITIES

Lead and manage all internal and external DMPK and clinical pharmacology activities, design and implement DMPK strategies to support discovery and development programs.

Provide scientific leadership and expertise to internal cross-functional teams, ensuring alignment with overall drug discovery / development goals.

Oversee non-clinical ADME / PK and PK / PD studies, manage CRO and collaboration with external experts to supplement internal capabilities.

Support regulatory submissions (INDs, NDAs) by providing DMPK and clinical pharmacology data, report and expertise.

Stay current with the latest advancements in DMPK, clinical pharmacology, and regulatory guidelines.

Ensure compliance with industry regulations and standards in all DMPK activities.

Participate in due diligence and business development activities as needed.

QUALIFICATIONS

PhD in relevant field such as Pharmacology, Biochemistry, Chemistry, Biology or related discipline

At least 10 years of experience in the pharmaceutical or biotechnology industry, with a focus on DMPK and or clinical pharmacology. At least 3 years of leadership experience in DMPK.

Proven experience in designing, conducting, and interpreting DMPK and / or clinical pharmacology studies supporting small molecule oncology programs.

Experience with regulatory submissions is required.

Expertise in regulatory requirements and industry standards for DMPK and clinical pharmacology studies (ICH guidelines, FDA regulations etc.).

Good exposure and experience in toxicology is a big plus.

Excellent communication, collaboration, and leadership skills.

Ability to work independently and manage multiple priorities in a fast-paced, team-oriented environment.

ABOUT IAMBIC THERAPEUTICS

Founded in 2019 and headquartered in San Diego, California, Iambic Therapeutics is disrupting the therapeutics landscape with its unique AI-driven drug-discovery platform. Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters with strong track records of success in delivering clinically validated therapeutics. The Iambic platform has been demonstrated to deliver high-quality, differentiated therapeutics to clinical stage with unprecedented speed and across multiple target classes and mechanisms of action. The Iambic team is advancing an internal pipeline of clinical assets to address urgent unmet patient needs. Learn more about the Iambic team, platform, and pipeline at iambic.ai.

MISSION & CORE VALUES

The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.

ALSO

We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life Insurance, 401K matching, and unlimited vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.