Senior Scientist- Immunology and Immunotherapy

Description

The Gnjatic Laboratory at Mount Sinai is seeking a highly motivated Senior Scientist with expertise in spatial pathology, multiplex immunohistochemistry, and computational analysis of tissue-based data. This is an exciting opportunity to work on cutting-edge technologies such as Visium, Visium HD, Codex, Orion, and CosMX, focusing on clinical trial samples to advance biomarker discovery and immunotherapy research.

The candidate will design and execute experiments, analyze complex spatial data, and collaborate closely with computational scientists and immunologists to uncover clinically relevant insights. This role offers an excellent environment for scientific growth, publication, and leadership in a highly collaborative research setting.

Responsibilities

• Lead research projects in multiplex immunohistochemistry and spatial transcriptomics, characterizing immune infiltration in various tissues (e.g., tumors, inflammatory lesions).
• Develop and validate novel tissue-based assays, ensuring robustness and reproducibility of results.
• Oversee and innovate multiplex immunohistochemical platforms, integrating advanced technologies like MICSSS, Visium, Codex, Orion, and CosMX.
• Analyze spatial and single-cell level data, utilizing computational tools for cell segmentation, tissue morphology, and immune profiling.
• Generate and interpret high-dimensional datasets, including immune cell density, spatial distribution, and proximity to tumor regions.
• Collaborate with computational biologists and clinical researchers, sharing findings and developing integrated pipelines for biomarker discovery.
• Present research at internal and external meetings, contribute to manuscripts and grant proposals, and engage in high-impact publications.

Why Join Us?

• Work with state-of-the-art technologies in a leading research institution.
• Directly impact immunotherapy and clinical research, working with real patient samples.
• Be part of an interdisciplinary team of scientists, computational biologists, and clinicians.
• Opportunities for career advancement through mentorship, funding applications, and leadership in high-profile projects.

We are looking for a passionate and driven scientist eager to push the boundaries of spatial pathology and immuno-oncology. If you're excited about working at the intersection of technology, pathology, and translational medicine, we encourage you to apply!

Qualifications

• M.D/Ph.D. in Pathology, Immunology, Cancer Biology, or related field.
• Ideally 5 years of experience in spatial pathology, multiplex imaging, and immuno-oncology research.
• Strong expertise in image analysis, tissue morphology, and immune profiling.
• Experience working with clinical trial samples and integrating data with patient outcomes.

Compensation

The Mount Sinai Health System (MSHS) provides salary ranges that comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $58661 - $150000 Annually. Actual salaries depend on a variety of factors, including experience, education, and operational need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.

Employer Description

Strength through Unity and Inclusion

The Mount Sinai Health System is committed to fostering an environment where everyone can contribute to excellence. We share a common dedication to delivering outstanding patient care. When you join us, you become part of Mount Sinai’s unparalleled legacy of achievement, education, and innovation as we work together to transform healthcare. We encourage all team members to actively participate in creating a culture that ensures fair access to opportunities, promotes inclusive practices, and supports the success of every individual.

At Mount Sinai, our leaders are committed to fostering a workplace where all employees feel valued, respected, and empowered to grow. We strive to create an environment where collaboration, fairness, and continuous learning drive positive change, improving the well-being of our staff, patients, and organization. Our leaders are expected to challenge outdated practices, promote a culture of respect, and work toward meaningful improvements that enhance patient care and workplace experiences. We are dedicated to building a supportive and welcoming environment where everyone has the opportunity to thrive and advance professionally. Explore this opportunity and be part of the next chapter in our history.

About the Mount Sinai Health System

Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 48,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time — discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment. The Health System includes more than 9,000 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics, top 5 in Cardiology/Heart Surgery, and top 20 in Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report’s “Best Children’s Hospitals” ranks Mount Sinai Kravis Children's Hospital among the country’s best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is ranked No. 11 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. Newsweek’s “The World’s Best Smart Hospitals” ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally.

Equal Opportunity Employer

The Mount Sinai Health System is an equal opportunity employer, complying with all applicable federal civil rights laws. We do not discriminate, exclude, or treat individuals differently based on race, color, national origin, age, religion, disability, sex, sexual orientation, gender, veteran status, or any other characteristic protected by law. We are deeply committed to fostering an environment where all faculty, staff, students, trainees, patients, visitors, and the communities we serve feel respected and supported. Our goal is to create a healthcare and learning institution that actively works to remove barriers, address challenges, and promote fairness in all aspects of our organization.