What are the responsibilities and job description for the Scientist Consultant, Antibody Discovery position at Integrated Resources, Inc ( IRI )?
Design strategies and execute antibody discovery campaigns for therapeutic and reagent antibodies using phage display
PhD in Biochemistry, Biomedical/Chemical Engineering, Immunology, or related field with minimum of 2 years of post-graduate experience (preferably in industry), MS with 8 years of research experience, BS with 10 years of research experience in antibody or protein engineering
- Generate antibody fragment libraries for antibody discovery and engineering, perform HT binding screens (ELISA and multi-plex flow cytometry) and sequence analysis to generate hits
- Rank-order clones by affinity, in vitro potency, and early developability assessment
- Execute sequence optimization of lead antibodies to improve developability and binding affinity
- Design and clone constructs for mAbs, bispecific, and multi-specific antibodies for recombinant antibody production
- Support NGS-based antibody discovery workflow
- Present data and updates to management and project teams
- Follow good documentation practice including maintaining good record keeping in Electronic Notebooks
PhD in Biochemistry, Biomedical/Chemical Engineering, Immunology, or related field with minimum of 2 years of post-graduate experience (preferably in industry), MS with 8 years of research experience, BS with 10 years of research experience in antibody or protein engineering
- Significant experience in antibody discovery and protein engineering by using single B cell cloning, hybridoma, or phage/yeast display techniques
- Strong background in molecular biology, antibody and protein expression, and biophysical characterization of recombinant antibodies and proteins
- Demonstrated experience in working collaboratively across various scientific disciplines and other parts of the organization to meet end goals
- Highly motivated individual with exceptionally good organizational skills, and attention to details
- Demonstrate ability to succeed in a fast-paced environment, working on multiple projects with constantly changing priorities and deadlines
- Excellent written and verbal communication skills
- Strong interpersonal skills
- Experience in single domain antibodies, multi-specific antibody engineering, Fc engineering, antibody drug conjugates, nai ¨ve phage or yeast display library design
- Experience in NGS analysis for antibody discovery and engineering
- Significant contributions to successful biologics drug discovery programs in biotech/biopharma industry
