What are the responsibilities and job description for the 2025 Ionis Summer Internship Program - Medicinal Chemistry position at Ionis Pharmaceuticals, Inc.?
Headquartered in Carlsbad, California, and with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been at work for more than three decades discovering medical breakthroughs that have redefined life for people with serious diseases. We’re pioneers in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. With multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals.
At Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees.
With an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our onsite, hybrid and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive.
We’re building on our rich history, and we believe our greatest achievements are ahead of us. If you’re passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career!
Medicinal Chemistry
Summary
A critical challenge in the successful development of siRNA-based therapeutics is enhancing their in vivo metabolic stability. We are seeking a summer intern to participate in the multi-step solution-phase synthesis of modified nucleosides and their characterization using analytical techniques such as NMR, LCMS, and HPLC. The intern will incorporate these nucleoside building blocks into siRNA sequences using automated solid-phase oligonucleotide synthesis. These modified siRNAs will be evaluated collaboratively for potency and duration of action in both cell cultures and mouse models. Additionally, biochemical assays will be conducted to assess the impact of these modifications on RISC loading and release mechanisms.
Program Highlights
The pay scale for this position is $18 to $23 per hour.
NO PHONE CALLS PLEASE. PRINCIPALS ONLY. APPLICATION DEADLINE IS April 30, 2025. PLEASE INCLUDE A COVER LETTER RELEVANT TO THE POSITION APPLYING FOR. THE EVALUATION PROCESS MAY COMMENCE PRIOR TO THIS DEADLINE.
Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers.
At Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees.
With an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our onsite, hybrid and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive.
We’re building on our rich history, and we believe our greatest achievements are ahead of us. If you’re passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career!
Medicinal Chemistry
Summary
A critical challenge in the successful development of siRNA-based therapeutics is enhancing their in vivo metabolic stability. We are seeking a summer intern to participate in the multi-step solution-phase synthesis of modified nucleosides and their characterization using analytical techniques such as NMR, LCMS, and HPLC. The intern will incorporate these nucleoside building blocks into siRNA sequences using automated solid-phase oligonucleotide synthesis. These modified siRNAs will be evaluated collaboratively for potency and duration of action in both cell cultures and mouse models. Additionally, biochemical assays will be conducted to assess the impact of these modifications on RISC loading and release mechanisms.
Program Highlights
- The program is designed to complement a student’s undergraduate studies with relevant, hands-on industry experience
- Ionis offers paid positions
- Weekly stipend (for onsite interns only)
- Professional Networking
- Fun Group Outings
- End-of-program project presentations
- Networking and bonding social events
- Interaction with diverse and motivated teams/departments
- MUST be currently enrolled in a U.S. Undergraduate Program and not graduating prior to the completion of the Ionis internship.
- MUST be able to begin internship between 6/9 and 6/16/2025
- MUST be able and willing to remain in the program through at least 8/15/2025
- MUST be able and willing to commit to a minimum 40-hour workweek and work onsite in Carlsbad, CA.
- Housing and travel assistance not provided for—local applicants with suitable transportation are preferred
The pay scale for this position is $18 to $23 per hour.
NO PHONE CALLS PLEASE. PRINCIPALS ONLY. APPLICATION DEADLINE IS April 30, 2025. PLEASE INCLUDE A COVER LETTER RELEVANT TO THE POSITION APPLYING FOR. THE EVALUATION PROCESS MAY COMMENCE PRIOR TO THIS DEADLINE.
Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers.
Salary : $18 - $23
