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Director, DMPK

Kardigan
South San Francisco, CA Full Time
POSTED ON 1/15/2025
AVAILABLE BEFORE 2/9/2025
About Us

Kardigan is a heart health company working to make cardiovascular disease preventable, curable and no longer the leading cause of death in the world. It is our mission to develop multiple targeted treatments in parallel that bring people with cardiovascular diseases to the cures they deserve.

At Kardigan, we are motivated by our values which guide how we work, interact, and achieve our goals. Driven by patients and their families, we are deeply committed to improving the lives of patients and prioritizing their needs above all else. We believe in being authentic—leading with truth to bring out the best in others by creating an environment where every person knows they will be fully accepted. With an eagerness to learn, we encourage the highest levels of curiosity and are open to changing our minds. We are committed to winning as a team with urgency, excellence, and intention, and support each other no matter what role we play or where we sit. Lastly, we strive to enable the impossible because patients are counting on us. We are not afraid to take risks to unlock innovation and advance scientific discoveries.  

These values are the foundation of our work, empowering us to make a real difference, every day. 

Position Title: Director of DMPK

Department: Discovery Research

Reports To: VP of Discovery Research

Job Overview

The Director of DMPK will build and lead the DMPK function in Discovery. Reporting to the VP of Discovery, this individual will build strong relationships across research, discovery, and development to enable the identification of best-in-class and first-in-class drug modalities. The role includes representing the DMPK function on project teams as well as supervising laboratory-based direct reports. They will also support research activities and the transition of assets from the discovery stage. The successful candidate should have significant experience in applying DMPK methodologies to drug discovery projects in the pharmaceutical industry.

Essential Duties And Responsibilities

  • Building and leading the DMPK function.
  • Managing and mentoring laboratory-based direct reports.
  • Representing the DMPK function on cross-functional drug discovery teams.
  • Establishing DMPK SOPs.
  • Reviewing and approving study protocols.
  • Experimental design and data interpretation.
  • Supporting the Discovery function by assessing developability, off-target activities, DDI potentials, dose- and PK projections.
  • Supporting the Research and Translational function through joint design of pharmacological studies, bio-analysis, and establishment of PK/PD relationships.
  • Managing CROs.

Qualifications And Preferred Skills

  • A PhD with a minimum of 6-8 years of experience in applying DMPK principles to drug discovery projects in the pharmaceutical/biotechnology industry.
  • Experience in LC/MS/MS bio-analytical method development and application.
  • Hands-on experience in modeling and simulations using PK analysis software tools (e.g., WinNonlin).
  • Experience in conducting, analyzing, and interpreting in vivo pharmacokinetic and PK/PD studies.
  • Experience assessing reactive metabolite formation.

Exact Compensation may vary based on skills, experience and location.

Pay range

$192,000 - $279,000 USD

Salary : $192,000 - $279,000

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