What are the responsibilities and job description for the (Senior) Principal Scientist, Immuno-oncology position at Legend Biotech US?
Company Information
Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell and natural killer (NK) cell-based immunotherapy.
Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel) in 2017. Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma.
Legend Biotech is seeking a ( Senior) Principal Scientist , Immuno-oncology as part of the Research & Early Development team based in Philadelphia, PA.
Role Overview
This position will the play an important role for a new interdisciplinary team developing company's cell therapy platform for solid tumor applications.
Qualified candidates should have extensive experience in innovative CAR-T research for oncology applications, and possess proficiency in CAR-T design, target selection and in vivo model development. Broad proficiency in Immuno-Oncology, such as T cell signaling, trafficking and differentiation, various suppressive mechanisms in tumor microenvironment, immune editing and antigen spreading. Candidates with experience in participation of IND-enabling studies, biomarker discovery and cell therapy process and or analytical development are preferred.
The candidate is expected to be driven, analytical, thoughtful, and creative, who can provide important strategic input for future directions for Solid tumor CAR-T development.
This position will report to the Senior Director of Research. Location : Philadelphia.
Key Responsibilities
- Lead the target and indication evaluation effort for internal next-gen CAR-T discovery.
- Design novel CAR signaling and armoring strategy to overcome on-target-off-tumor toxicity.
- Design and execute in vitro and in vivo functional assays.
- Analyze and interpret data, troubleshooting, engage internal stakeholders and cross-functional teams.
- Stay abreast of the latest advancement of cell therapy in solid tumor. Demonstrate deep insight in selected disease area.
Requirements
Li-Onsite
Li-JR1
Legend Biotech is a proud equal opportunity / affirmative action employer committed to attracting, retaining, and maximizing the performance of a diverse and inclusive workforce. It is Legend's policy to ensure equal employment opportunity without discrimination or harassment based on race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, age, disability, national origin, marital or domestic / civil partnership status, genetic information, citizenship status, uniformed service member or veteran status, or any other characteristic protected by law.
Legend Biotech maintains a drug-free workplace.
